Arginase 1 (Arg1) as an Up-Regulated Gene in COVID-19 Patients: A Promising Marker in COVID-19 Immunopathy.
J Clin Med
; 10(5)2021 Mar 04.
Article
in English
| MEDLINE | ID: covidwho-1124853
Semantic information from SemMedBD (by NLM)
1. ARG1 gene|ARG1 STIMULATES Genes
2. COVID-19 PROCESS_OF Patients
3. Patients LOCATION_OF Genes
4. COVID-19 AFFECTS Immune response
5. ARG1 gene|ARG1 INTERACTS_WITH Immune Cell
6. Real-Time Polymerase Chain Reaction MEASURES Anabolism
7. ARG1 gene|ARG1 LOCATION_OF Gene Expression
8. Patients LOCATION_OF ARG1 gene|ARG1
9. peripheral blood PART_OF Patients
10. ARG1 gene|ARG1 CAUSES Disease
11. ARG1 gene|ARG1 STIMULATES Genes
12. COVID-19 PROCESS_OF Patients
13. Patients LOCATION_OF Genes
14. COVID-19 AFFECTS Immune response
15. ARG1 gene|ARG1 INTERACTS_WITH Immune Cell
16. Real-Time Polymerase Chain Reaction MEASURES Anabolism
17. ARG1 gene|ARG1 LOCATION_OF Gene Expression
18. Patients LOCATION_OF ARG1 gene|ARG1
19. peripheral blood PART_OF Patients
20. ARG1 gene|ARG1 CAUSES Disease
ABSTRACT
BACKGROUND:
The coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global pandemic. It is well-established that SARS-CoV-2 infection can lead to dysregulated immune responses. Arginase-1 (Arg1), which has a pivotal role in immune cells, can be expressed in most of the myeloid cells, e.g., neutrophils and macrophages. Arg1 has been associated with the suppression of antiviral immune responses.METHODS:
Whole blood was taken from 21 COVID-19 patients and 21 healthy individuals, and after RNA extraction and complementary DNA (cDNA) synthesis, gene expression of Arg1 was measured by real-time PCR.RESULTS:
The qPCR results showed that the expression of Arg1 was significantly increased in COVID-19 patients compared to healthy individuals (p < 0.01). The relative expression analysis demonstrated there were approximately 2.3 times increased Arg1 expression in the whole blood of COVID-19 patients. Furthermore, the receiver operating characteristic (ROC) analysis showed a considerable diagnostic value for Arg1 expression in COVID-19 (p = 0.0002 and AUC = 0.8401).CONCLUSION:
Arg1 might be a promising marker in the pathogenesis of the disease, and it could be a valuable diagnostic tool.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Jcm10051051
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