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Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress.
Hirano, Shin-Ichi; Ichikawa, Yusuke; Sato, Bunpei; Yamamoto, Haru; Takefuji, Yoshiyasu; Satoh, Fumitake.
  • Hirano SI; Department of Research and Development, MiZ Company Limited, 2-19-15 Ofuna, Kamakura, Kanagawa 247-0056, Japan.
  • Ichikawa Y; Department of Research and Development, MiZ Company Limited, 2-19-15 Ofuna, Kamakura, Kanagawa 247-0056, Japan.
  • Sato B; Department of Research and Development, MiZ Company Limited, 2-19-15 Ofuna, Kamakura, Kanagawa 247-0056, Japan.
  • Yamamoto H; Department of Molecular & Cell Biology, University of California, 3060 Valley Life Sciences Bldg #3140, Berkeley, CA 94720-3140, USA.
  • Takefuji Y; Faculty of Environment and Information Studies, Keio University, 5322 Endo, Fujisawa 252-0882, Japan.
  • Satoh F; Department of Research and Development, MiZ Company Limited, 2-19-15 Ofuna, Kamakura, Kanagawa 247-0056, Japan.
Int J Mol Sci ; 22(5)2021 Mar 04.
Article in English | MEDLINE | ID: covidwho-1125259
ABSTRACT
Mitochondria are the largest source of reactive oxygen species (ROS) and are intracellular organelles that produce large amounts of the most potent hydroxyl radical (·OH). Molecular hydrogen (H2) can selectively eliminate ·OH generated inside of the mitochondria. Inflammation is induced by the release of proinflammatory cytokines produced by macrophages and neutrophils. However, an uncontrolled or exaggerated response often occurs, resulting in severe inflammation that can lead to acute or chronic inflammatory diseases. Recent studies have reported that ROS activate NLRP3 inflammasomes, and that this stimulation triggers the production of proinflammatory cytokines. It has been shown in literature that H2 can be based on the mechanisms that inhibit mitochondrial ROS. However, the ability for H2 to inhibit NLRP3 inflammasome activation via mitochondrial oxidation is poorly understood. In this review, we hypothesize a possible mechanism by which H2 inhibits mitochondrial oxidation. Medical applications of H2 may solve the problem of many chronic inflammation-based diseases, including coronavirus disease 2019 (COVID-19).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hydrogen / Inflammation / Mitochondria Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22052549

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hydrogen / Inflammation / Mitochondria Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22052549