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The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.
Groves, Danielle C; Rowland-Jones, Sarah L; Angyal, Adrienn.
  • Groves DC; Florey Institute for Host-Pathogen Interactions and the Department of Infection, Immunity and Cardiovascular Science (IICD), Sheffield University Medical School, Beech Hill Road, Sheffield, S. Yorkshire, S102RX, United Kingdom.
  • Rowland-Jones SL; Florey Institute for Host-Pathogen Interactions and the Department of Infection, Immunity and Cardiovascular Science (IICD), Sheffield University Medical School, Beech Hill Road, Sheffield, S. Yorkshire, S102RX, United Kingdom. Electronic address: s.l.rowland-jones@sheffield.ac.uk.
  • Angyal A; Florey Institute for Host-Pathogen Interactions and the Department of Infection, Immunity and Cardiovascular Science (IICD), Sheffield University Medical School, Beech Hill Road, Sheffield, S. Yorkshire, S102RX, United Kingdom.
Biochem Biophys Res Commun ; 538: 104-107, 2021 01 29.
Article in English | MEDLINE | ID: covidwho-1125671
ABSTRACT
The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Evolution, Molecular / Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Biochem Biophys Res Commun Year: 2021 Document Type: Article Affiliation country: J.bbrc.2020.10.109

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Evolution, Molecular / Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Biochem Biophys Res Commun Year: 2021 Document Type: Article Affiliation country: J.bbrc.2020.10.109