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Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario.
Tonelli, Roberto; Marchioni, Alessandro; Tabbì, Luca; Fantini, Riccardo; Busani, Stefano; Castaniere, Ivana; Andrisani, Dario; Gozzi, Filippo; Bruzzi, Giulia; Manicardi, Linda; Demurtas, Jacopo; Andreani, Alessandro; Cappiello, Gaia Francesca; Samarelli, Anna Valeria; Clini, Enrico.
  • Tonelli R; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Marchioni A; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Tabbì L; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Fantini R; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Busani S; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Castaniere I; Intensive Care Unit, University Hospital of Modena and Reggio Emilia, 41124 Modena, Italy.
  • Andrisani D; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Gozzi F; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Bruzzi G; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Manicardi L; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Demurtas J; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Andreani A; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Cappiello GF; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Samarelli AV; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41124 Modena, Italy.
  • Clini E; Primary Care Department USL Toscana Sud Est-Grosseto, 58100 Grosseto, Italy.
J Clin Med ; 10(5)2021 Mar 02.
Article in English | MEDLINE | ID: covidwho-1125725
Semantic information from SemMedBD (by NLM)
1. Spontaneous respiration PROCESS_OF Patients
Subject
Spontaneous respiration
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Spontaneous respiration PROCESS_OF Patients
Subject
Spontaneous respiration
Predicate
PROCESS_OF
Object
Patients
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
The mechanisms of acute respiratory failure other than inflammation and complicating the SARS-CoV-2 infection are still far from being fully understood, thus challenging the management of COVID-19 patients in the critical care setting. In this unforeseen scenario, the role of an individual's excessive spontaneous breathing may acquire critical importance, being one potential and important driver of lung injury and disease progression. The consequences of this acute lung damage may impair lung structure, forecasting the model of a fragile respiratory system. This perspective article aims to analyze the progression of injured lung phenotypes across the SARS-CoV-2 induced respiratory failure, pointing out the role of spontaneous breathing and also tackling the specific respiratory/ventilatory strategy required by the fragile lung type.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Evidence synthesis Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10050975

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Evidence synthesis Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10050975