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Clinical features and prognostic factors of critically ill patients with COVID-19 in Daegu, South Korea: A multi-center retrospective study.
Kim, Eun Jin; Lee, Yong Hoon; Park, Jae Seok; Lee, Jaehee; Lee, Shin Yup; Kim, Yeonjae; Kwon, Yong Shik; Jang, Jong Geol; Shin, Kyeong-Cheol; Kim, Kyung Chan; Choi, Eun Young.
  • Kim EJ; Division of Pulmonary and Critical Care Medicine, Daegu Catholic university hospital.
  • Lee YH; Department of Internal Medicine, School of Medicine, Kyungpook National University.
  • Park JS; Division of Pulmonology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine.
  • Lee J; Department of Internal Medicine, School of Medicine, Kyungpook National University.
  • Lee SY; Division of Pulmonary and Critical Care Medicine, Kyungpook National University Chilgok Hospital.
  • Kim Y; Division of Pulmonary and Critical Care Medicine, Deagu Fatima Hospital.
  • Kwon YS; Division of Pulmonology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine.
  • Jang JG; Division of Pulmonary and Critical Care Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea.
  • Shin KC; Division of Pulmonary and Critical Care Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea.
  • Kim KC; Division of Pulmonary and Critical Care Medicine, Daegu Catholic university hospital.
  • Choi EY; Division of Pulmonary and Critical Care Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea.
Medicine (Baltimore) ; 100(7): e24437, 2021 Feb 19.
Article in English | MEDLINE | ID: covidwho-1125890
ABSTRACT
ABSTRACT To describe the clinical and demographic characteristics of critically ill patients with COVID-19 in Daegu, South Korea, and to explore the risk factors for in-hospital mortality in these patients.Retrospective cohort study of 110 critically ill patients with COVID-19 admitted to the ICU in Daegu, South Korea, between February 18 and April 5, 2020. The final date of follow-up was April 20, 2020.A total of 110 patient medical records were reviewed. The median age was 71 years (interquartile range [IQR] = 63-78 years). During the study period, 47 patients (42.7%) died in the hospital. The most common SARS-CoV-2 infection related complication was acute respiratory distress syndrome (ARDS) in 95 patients (86.4%). Of the 79 patients (71.8%) who received invasive mechanical ventilation, 46 (58.2%) received neuromuscular blockade injection, and 19 (24.1%) received ECMO treatment. All patients received antibiotic injection, 99 patients (90%) received hydroxychloroquine, 96 patients (87.3%) received lopinavir-ritonavir antiviral medication, and 14 patients (12.7%) received other antiviral agents, including darunavir-cobicistat and emtricitabine-tenofovir. In the multivariable logistic regression model, the odds ratio of in-hospital death was higher with APACHE II score (OR = 1.126; 95% CI = 1.014-1.252; P  = .027).The in-hospital mortality rate of critically ill patients with COVID-19 was approximately 40%. Higher APACHE II score at admission was an independent risk factor for death in these patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Critical Illness / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Critical Illness / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article