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The effect of semen collection location and time to processing on sperm parameters and early IVF/ICSI outcomes.
Sacha, Caitlin R; Vagios, Stylianos; Hammer, Karissa; Fitz, Victoria; Souter, Irene; Bormann, Charles L.
  • Sacha CR; Massachusetts General Hospital Fertility Center, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street-Yawkey 10A, Boston, MA, 02114, USA. CSACHA@partners.org.
  • Vagios S; Massachusetts General Hospital Fertility Center, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street-Yawkey 10A, Boston, MA, 02114, USA.
  • Hammer K; Massachusetts General Hospital Fertility Center, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street-Yawkey 10A, Boston, MA, 02114, USA.
  • Fitz V; Massachusetts General Hospital Fertility Center, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street-Yawkey 10A, Boston, MA, 02114, USA.
  • Souter I; Massachusetts General Hospital Fertility Center, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street-Yawkey 10A, Boston, MA, 02114, USA.
  • Bormann CL; Massachusetts General Hospital Fertility Center, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street-Yawkey 10A, Boston, MA, 02114, USA.
J Assist Reprod Genet ; 38(6): 1449-1457, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1126571
ABSTRACT

PURPOSE:

We aimed to assess whether home collection and increased time to semen processing are associated with altered sperm parameters, fertilization rates (FR), day 5 usable quality blastocyst development rates (D5-UQBR), or pregnancy rates (PR) in patients undergoing IVF/ICSI.

METHODS:

This was a retrospective cohort study of patients undergoing IVF/ICSI before the coronavirus disease 2019 (COVID-19) pandemic ("clinic" collection, n = 119) and after COVID-19 ("home" collection, n = 125) at an academic fertility practice. Home collection occurred within 2 h of semen processing. Patient sperm parameters, FR (#2PN/MII), D5-UQBR (# transferable and freezable quality blastocysts/# 2PN), and PR in fresh transfer cycles were compared between clinic and home groups with t-tests. The association between time to processing on outcomes was assessed with regression modeling, controlling for potential confounders.

RESULTS:

Mean male age was 37.9 years in the clinic group and 37.2 years in the home group (p = 0.380). On average, men were abstinent for 3.0 days (SD 1.7) in the clinic group and 4.1 days (SD 5.4) in the home group (p = 0.028). Mean time to semen processing was 35.7 min (SD 9.4) in the clinic group and 82.6 min (SD 33.8) in the home group (p < 0.001). There was no association between collection location and increased time to processing on sperm motility, total motile count, FR, D5-UQBR, or PR.

CONCLUSIONS:

Our data suggest that increased time to processing up to 2 h with home semen collection does not negatively impact sperm parameters or early IVF/ICSI outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Semen / Semen Preservation / Spermatozoa / Blastocyst / Pregnancy Rate / Fertilization Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Limits: Adult / Female / Humans / Male / Pregnancy Language: English Journal: J Assist Reprod Genet Journal subject: Genetics / Reproductive Medicine Year: 2021 Document Type: Article Affiliation country: S10815-021-02128-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Semen / Semen Preservation / Spermatozoa / Blastocyst / Pregnancy Rate / Fertilization Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Limits: Adult / Female / Humans / Male / Pregnancy Language: English Journal: J Assist Reprod Genet Journal subject: Genetics / Reproductive Medicine Year: 2021 Document Type: Article Affiliation country: S10815-021-02128-x