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Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors.
Milani, Mario; Donalisio, Manuela; Bonotto, Rafaela Milan; Schneider, Edoardo; Arduino, Irene; Boni, Francesco; Lembo, David; Marcello, Alessandro; Mastrangelo, Eloise.
  • Milani M; CNR-IBF, Istituto di Biofisica, Via Celoria 26, I-20133, Milano, Italy; Dipartimento di Bioscienze, Università di Milano, Via Celoria 26, I-20133, Milano, Italy.
  • Donalisio M; Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Regione Gonzole, 10, I-10043, Orbassano, Turin, Italy.
  • Bonotto RM; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149, Trieste, Italy.
  • Schneider E; High Throughput Screening Facility of the International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149, Trieste, Italy.
  • Arduino I; Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Regione Gonzole, 10, I-10043, Orbassano, Turin, Italy.
  • Boni F; CNR-IBF, Istituto di Biofisica, Via Celoria 26, I-20133, Milano, Italy; Dipartimento di Bioscienze, Università di Milano, Via Celoria 26, I-20133, Milano, Italy.
  • Lembo D; Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Regione Gonzole, 10, I-10043, Orbassano, Turin, Italy.
  • Marcello A; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149, Trieste, Italy. Electronic address: marcello@icgeb.org.
  • Mastrangelo E; CNR-IBF, Istituto di Biofisica, Via Celoria 26, I-20133, Milano, Italy; Dipartimento di Bioscienze, Università di Milano, Via Celoria 26, I-20133, Milano, Italy. Electronic address: eloise.mastrangelo@cnr.it.
Antiviral Res ; 189: 105055, 2021 05.
Article in English | MEDLINE | ID: covidwho-1126674
ABSTRACT
The current emergency of the novel coronavirus SARS-CoV2 urged the need for broad-spectrum antiviral drugs as the first line of treatment. Coronaviruses are a large family of viruses that already challenged humanity in at least two other previous outbreaks and are likely to be a constant threat for the future. In this work we developed a pipeline based on in silico docking of known drugs on SARS-CoV1/2 RNA-dependent RNA polymerase combined with in vitro antiviral assays on both SARS-CoV2 and the common cold human coronavirus HCoV-OC43. Results showed that certain drugs displayed activity for both viruses at a similar inhibitory concentration, while others were specific. In particular, the antipsychotic drug lurasidone and the antiviral drug elbasvir showed promising activity in the low micromolar range against both viruses with good selectivity index.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Benzofurans / Coronavirus OC43, Human / Drug Repositioning / Lurasidone Hydrochloride / SARS-CoV-2 / Imidazoles Limits: Animals / Humans Language: English Journal: Antiviral Res Year: 2021 Document Type: Article Affiliation country: J.antiviral.2021.105055

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Benzofurans / Coronavirus OC43, Human / Drug Repositioning / Lurasidone Hydrochloride / SARS-CoV-2 / Imidazoles Limits: Animals / Humans Language: English Journal: Antiviral Res Year: 2021 Document Type: Article Affiliation country: J.antiviral.2021.105055