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Predicting and Preventing Immune Checkpoint Inhibitor Toxicity: Targeting Cytokines.
Kang, Jee Hye; Bluestone, Jeffrey A; Young, Arabella.
  • Kang JH; Sean N. Parker Autoimmune Research Laboratory and Diabetes Center, University of California San Francisco, San Francisco, CA, USA.
  • Bluestone JA; Sean N. Parker Autoimmune Research Laboratory and Diabetes Center, University of California San Francisco, San Francisco, CA, USA; Sonoma Biotherapeutics, South San Francisco, CA, USA.
  • Young A; Sean N. Parker Autoimmune Research Laboratory and Diabetes Center, University of California San Francisco, San Francisco, CA, USA; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. Electronic address: arabella.young@ucsf.edu.
Trends Immunol ; 42(4): 293-311, 2021 04.
Article in English | MEDLINE | ID: covidwho-1126887
ABSTRACT
Cancer immunotherapies can successfully activate immune responses towards certain tumors. However, this can also result in the development of treatment-induced immune-related adverse events (irAEs) in multiple tissues. Growing evidence suggests that cytokine production in response to these therapeutics potentiates the development of irAEs and may have predictive value as biomarkers for irAE occurrence. In addition, therapeutic agents that inhibit cytokine activity can limit the severity of irAEs, and their use is being tested in the clinical setting. This review provides an in-depth analysis of strategies to uncouple the cytokine response, that precipitates irAEs following cancer immunotherapies, from the benefit gained in promoting antitumor immunity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / Immune Checkpoint Inhibitors / Neoplasms Type of study: Prognostic study Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.it.2021.02.006

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / Immune Checkpoint Inhibitors / Neoplasms Type of study: Prognostic study Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.it.2021.02.006