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Factors linked to severe outcomes in multisystem inflammatory syndrome in children (MIS-C) in the USA: a retrospective surveillance study.
Abrams, Joseph Y; Oster, Matthew E; Godfred-Cato, Shana E; Bryant, Bobbi; Datta, S Deblina; Campbell, Angela P; Leung, Jessica W; Tsang, Clarisse A; Pierce, Timmy J; Kennedy, Jordan L; Hammett, Teresa A; Belay, Ermias D.
  • Abrams JY; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: jabrams@cdc.gov.
  • Oster ME; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Godfred-Cato SE; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Bryant B; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
  • Datta SD; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Campbell AP; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Leung JW; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Tsang CA; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Pierce TJ; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Kennedy JL; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Hammett TA; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Belay ED; CDC COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Lancet Child Adolesc Health ; 5(5): 323-331, 2021 05.
Article in English | MEDLINE | ID: covidwho-1127105
Semantic information from SemMedBD (by NLM)
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ABSTRACT

BACKGROUND:

Multisystem inflammatory syndrome in children (MIS-C) is a newly identified and serious health condition associated with SARS-CoV-2 infection. Clinical manifestations vary widely among patients with MIS-C, and the aim of this study was to investigate factors associated with severe outcomes.

METHODS:

In this retrospective surveillance study, patients who met the US Centers for Disease Control and Prevention (CDC) case definition for MIS-C (younger than 21 years, fever, laboratory evidence of inflammation, admitted to hospital, multisystem [≥2] organ involvement [cardiac, renal, respiratory, haematological, gastrointestinal, dermatological, or neurological], no alternative plausible diagnosis, and either laboratory confirmation of SARS-CoV-2 infection by RT-PCR, serology, or antigen test, or known COVID-19 exposure within 4 weeks before symptom onset) were reported from state and local health departments to the CDC using standard case-report forms. Factors assessed for potential links to severe outcomes included pre-existing patient factors (sex, age, race or ethnicity, obesity, and MIS-C symptom onset date before June 1, 2020) and clinical findings (signs or symptoms and laboratory markers). Logistic regression models, adjusted for all pre-existing factors, were used to estimate odds ratios between potential explanatory factors and the following

outcomes:

intensive care unit (ICU) admission, shock, decreased cardiac function, myocarditis, and coronary artery abnormalities.

FINDINGS:

1080 patients met the CDC case definition for MIS-C and had symptom onset between March 11 and Oct 10, 2020. ICU admission was more likely in patients aged 6-12 years (adjusted odds ratio 1·9 [95% CI 1·4-2·6) and patients aged 13-20 years (2·6 [1·8-3·8]), compared with patients aged 0-5 years, and more likely in non-Hispanic Black patients, compared with non-Hispanic White patients (1·6 [1·0-2·4]). ICU admission was more likely for patients with shortness of breath (1·9 [1·2-2·9]), abdominal pain (1·7 [1·2-2·7]), and patients with increased concentrations of C-reactive protein, troponin, ferritin, D-dimer, brain natriuretic peptide (BNP), N-terminal pro B-type BNP, or interleukin-6, or reduced platelet or lymphocyte counts. We found similar associations for decreased cardiac function, shock, and myocarditis. Coronary artery abnormalities were more common in male patients (1·5 [1·1-2·1]) than in female patients and patients with mucocutaneous lesions (2·2 [1·3-3·5]) or conjunctival injection (2·3 [1·4-3·7]).

INTERPRETATION:

Identification of important demographic and clinical characteristics could aid in early recognition and prompt management of severe outcomes for patients with MIS-C.

FUNDING:

None.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn / Young adult Country/Region as subject: North America Language: English Journal: Lancet Child Adolesc Health Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn / Young adult Country/Region as subject: North America Language: English Journal: Lancet Child Adolesc Health Year: 2021 Document Type: Article