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The Synthesis of a Two-Photon Fluorescence Labelling Probe and its Immunochromatographic Strip for Rapid Diagnosis of COVID-19
Australian Journal of Chemistry ; : 7, 2021.
Article in English | Web of Science | ID: covidwho-1127219
ABSTRACT
A two-photon fluorescence labelling probe (LP) was synthesised, and LP-Ag was obtained by LP labelling the N-protein antigen (Ag) of COVID-19. LP-Ag was made into an immunochromatographic strip. When a blood sample was added to the sample hole of the test card, it would move forward along the nitrocellulose (NC) film. If the sample contained IgM, the IgM bound to LP-Ag and formed anMline with the coated mouse anti-human IgM antibody, giving a positive response to the presence of IgM of COVID-19. The sensitivity, specificity, and accuracy of the immunochromatographic strip based on the LP was compared with those of the nucleic acid detection method and the colloidal gold method, proving it to be much simpler than the nucleic acid detection method, which can greatly shorten the detection period, and to be much more stable than the colloidal gold method, which can overcome uncertainty. LP-Ag can be used to image lung tissue with COVID-19 by two-photon fluorescence microscopy (TFM).

Full text: Available Collection: Databases of international organizations Database: Web of Science Language: English Journal: Australian Journal of Chemistry Year: 2021 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Web of Science Language: English Journal: Australian Journal of Chemistry Year: 2021 Document Type: Article