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Dexamethasone use and mortality in hospitalized patients with coronavirus disease 2019: A multicentre retrospective observational study.
Hoertel, Nicolas; Sánchez-Rico, Marina; Vernet, Raphaël; Beeker, Nathanaël; Neuraz, Antoine; Alvarado, Jesús M; Daniel, Christel; Paris, Nicolas; Gramfort, Alexandre; Lemaitre, Guillaume; Salamanca, Elisa; Bernaux, Mélodie; Bellamine, Ali; Burgun, Anita; Limosin, Frédéric.
  • Hoertel N; Département de Psychiatrie, AP-HP.Centre, Hôpital Corentin-Celton, Issy-les-Moulineaux, France.
  • Sánchez-Rico M; Institut de Psychiatrie et Neurosciences de Paris, Université de Paris, INSERM, Paris, France.
  • Vernet R; Faculté de Santé, UFR de Médecine, Université de Paris, Paris, France.
  • Beeker N; Département de Psychiatrie, AP-HP.Centre, Hôpital Corentin-Celton, Issy-les-Moulineaux, France.
  • Neuraz A; Department of Psychobiology & Behavioural Sciences Methods, Faculty of Psychology, Universidad Complutense de Madrid, Campus de Somosaguas, Pozuelo de Alarcon, Spain.
  • Alvarado JM; Hôpital Européen Georges Pompidou, Medical Informatics, Biostatistics and Public Health Department, AP-HP.Centre-Université de Paris, Paris, France.
  • Daniel C; Unité de Recherche clinique, Hopital Cochin, Assistance Publique-Hopitaux de Paris, Paris, France.
  • Paris N; INSERM, UMR_S 1138, Cordeliers Research Center, Université de Paris, France.
  • Gramfort A; Department of Medical Informatics, Necker-Enfants Malades Hospital, AP-HP. Centre-Université de Paris, Paris, France.
  • Lemaitre G; Department of Psychobiology & Behavioural Sciences Methods, Faculty of Psychology, Universidad Complutense de Madrid, Campus de Somosaguas, Pozuelo de Alarcon, Spain.
  • Salamanca E; AP-HP, DSI-WIND (Web Innovation Données), Paris, France.
  • Bernaux M; Sorbonne University, University Paris 13, Sorbonne Paris Cité, INSERM UMR_S 1142, Paris, France.
  • Bellamine A; AP-HP, DSI-WIND (Web Innovation Données), Paris, France.
  • Burgun A; LIMSI, CNRS, Université Paris-Sud, Université Paris-Saclay, Orsay, France.
  • Limosin F; Université Paris-Saclay, INRIA, CEA, Palaiseau, France.
Br J Clin Pharmacol ; 87(10): 3766-3775, 2021 10.
Article in English | MEDLINE | ID: covidwho-1127455
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ABSTRACT

AIMS:

To examine the association between dexamethasone use and mortality among patients hospitalized for COVID-19.

METHODS:

We examined the association between dexamethasone use and mortality at AP-HP Greater Paris University hospitals. Study baseline was defined as the date of hospital admission. The primary endpoint was time to death. We compared this endpoint between patients who received dexamethasone and those who did not in time-to-event analyses adjusted for patient characteristics (such as age, sex and comorbidity) and clinical and biological markers of clinical severity of COVID-19, and stratified by the need for respiratory support, i.e. mechanical ventilation or oxygen. The primary analysis was a multivariable Cox regression model.

RESULTS:

Of 12 217 adult patients hospitalized with a positive COVID-19 reverse transcriptase-polymerase chain reaction test, 171 (1.4%) received dexamethasone orally or by intravenous perfusion during the visit. Among patients who required respiratory support, the end-point occurred in 10/63 (15.9%) patients who received dexamethasone and 298/1129 (26.4%) patients who did not. In this group, there was a significant association between dexamethasone use and reduced mortality in the primary analysis (hazard ratio, 0.46; 95% confidence interval 0.22-0.96, P = .039). Among patients who did not require respiratory support, there was no significant association between dexamethasone use and the endpoint.

CONCLUSIONS:

In this multicentre observational study, dexamethasone use administered either orally or by intravenous injection at a cumulative dose between 60 mg and 150 mg was associated with reduced mortality among patients with COVID-19 requiring respiratory support.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / COVID-19 Drug Treatment Type of study: Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: Br J Clin Pharmacol Year: 2021 Document Type: Article Affiliation country: Bcp.14784

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / COVID-19 Drug Treatment Type of study: Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: Br J Clin Pharmacol Year: 2021 Document Type: Article Affiliation country: Bcp.14784