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The COVID-Kidney Controversy: Can SARS-CoV-2 Cause Direct Renal Infection?
Lau, Wei Ling; Zuckerman, Jonathan E; Gupta, Ajay; Kalantar-Zadeh, Kamyar.
  • Lau WL; Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, California, USA.
  • Zuckerman JE; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
  • Gupta A; Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, California, USA.
  • Kalantar-Zadeh K; Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, California, USA, kkz@uci.edu.
Nephron ; 145(3): 275-279, 2021.
Article in English | MEDLINE | ID: covidwho-1127626
ABSTRACT
CONTEXT Determining whether SARS-CoV-2 causes direct infection of the kidneys is challenging due to limitations in imaging and molecular tools. Subject of Review A growing number of conflicting kidney biopsy and autopsy reports highlight this controversial issue. Second Opinion Based on the collective evidence, therapies that improve hemodynamic stability and oxygenation, or dampen complement activation, are likely to ameliorate acute kidney injury in COVID-19. At this time, whether inhibition of viral infection and replication directly modulates kidney damage is inconclusive.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Kidney Diseases Topics: Long Covid Limits: Humans Language: English Journal: Nephron Year: 2021 Document Type: Article Affiliation country: 000513789

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Kidney Diseases Topics: Long Covid Limits: Humans Language: English Journal: Nephron Year: 2021 Document Type: Article Affiliation country: 000513789