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Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction.
Xiang, Pan; Xu, Xinmin; Lu, Xin; Gao, Lili; Wang, Huizhu; Li, Zhenpeng; Xiong, Haofeng; Li, Ruihong; Xiong, Yanwen; Pu, Lin; Qin, Tian; Jin, Fangfang; Ren, Hongyu; Li, Chuansheng; Yang, Jing; Zhang, Ming; Gong, Jie; Chen, Xiaoping; Zheng, Han; Tan, Jianbo; Sun, Yao; Zhao, Fei; Hou, Xuexin; Liu, Yufeng; Guo, Hebing; Hao, Jingjing; Kan, Biao; Zhou, Haijian; Wang, Yajie; Liu, Jingyuan.
  • Xiang P; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Xu X; Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Lu X; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Gao L; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Wang H; Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Li Z; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Xiong H; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Li R; Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Xiong Y; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Pu L; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Qin T; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Jin F; Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Ren H; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Li C; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Yang J; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Zhang M; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Gong J; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Chen X; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Zheng H; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Tan J; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Sun Y; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Zhao F; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Hou X; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Liu Y; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Guo H; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Hao J; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Kan B; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Zhou H; State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
  • Wang Y; Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Liu J; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Front Med (Lausanne) ; 8: 629828, 2021.
Article in English | MEDLINE | ID: covidwho-1127988
ABSTRACT
We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and a significant increase in intracranial pressure developed in an adult coronavirus disease 2019 patient. The complete genome sequence of SARS-CoV-2 obtained from the cerebrospinal fluid indicates that SARS-CoV-2 can invade the central nervous system. In future, along with nervous system assessment, the pathogen genome detection and other indicators are needed for studying possible nervous system infection of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Language: English Journal: Front Med (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fmed.2021.629828

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Language: English Journal: Front Med (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fmed.2021.629828