Dipeptidyl peptidase 4 inhibitors: Applications in innate immunity?
Biochem Pharmacol
; 188: 114517, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1128904
ABSTRACT
Dipeptidyl peptidase (DPP)-4 inhibitors are a class of orally available, small molecule inhibitors that prolong the insulinotropic activity of the incretin hormone glucagon-like peptide-1 (GLP-1) and are highly effective for the treatment of Type-2 diabetes. DPP4 can also cleave several immunoregulatory peptides including chemokines. Emerging evidence continues to implicate DPP4 inhibitors as immunomodulators, with recent findings suggesting DPP4 inhibitors modify specific aspects of innate immunity. This review summarises recent insights into how DPP4 inhibitors could be implicated in endothelial, neutrophil and monocyte/macrophage mediated immunity. Additionally, this review highlights additional avenues of research with DPP4 inhibitors in the context of the COVID-19 pandemic.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Dipeptidyl-Peptidase IV Inhibitors
/
SARS-CoV-2
/
COVID-19 Drug Treatment
/
Immunity, Innate
Limits:
Animals
/
Humans
Language:
English
Journal:
Biochem Pharmacol
Year:
2021
Document Type:
Article
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