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The potential for Lactoferrin to reduce SARS-CoV-2 induced cytokine storm.
Zimecki, Michal; Actor, Jeffrey K; Kruzel, Marian L.
  • Zimecki M; The Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
  • Actor JK; University of Texas, Health Science Center Houston, Texas, USA. Electronic address: Jeffrey.K.Actor@uth.tmc.edu.
  • Kruzel ML; University of Texas, Health Science Center Houston, Texas, USA.
Int Immunopharmacol ; 95: 107571, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1129045
ABSTRACT
The COVID-19 pandemic is a serious global health threat caused by severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2). Symptoms of COVID-19 are highly variable with common hyperactivity of immune responses known as a "cytokine storm". In fact, this massive release of inflammatory cytokines into in the pulmonary alveolar structure is a main cause of mortality during COVID-19 infection. Current management of COVID-19 is supportive and there is no common clinical protocol applied to suppress this pathological state. Lactoferrin (LF), an iron binding protein, is a first line defense protein that is present in neutrophils and excretory fluids of all mammals, and is well recognized for its role in maturation and regulation of immune system function. Also, due to its ability to sequester free iron, LF is known to protect against insult-induced oxidative stress and subsequent "cytokine storm" that results in dramatic necrosis within the affected tissue. Review of the literature strongly suggests utility of LF to silence the "cytokine storm", giving credence to both prophylactic and therapeutic approaches towards combating COVID-19 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / COVID-19 / Lactoferrin Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2021 Document Type: Article Affiliation country: J.intimp.2021.107571

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / COVID-19 / Lactoferrin Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2021 Document Type: Article Affiliation country: J.intimp.2021.107571