COVID-19-related cognitive dysfunction may be associated with transient disruption in the DLPFC glutamatergic pathway.
J Clin Neurosci
; 87: 153-155, 2021 May.
Article
in English
| MEDLINE | ID: covidwho-1129084
ABSTRACT
Cognitive impairment has recently attracted researchers as one of the possible neuropsychiatric manifestations of COVID-19, although how the infection perpetuates impairment of cognitive functions is still obscure. We presented a 29-year-old male patient with COVID-19 who developed new-onset transient attention deficit and memory problems following a SARS-CoV-2 infection. Structural neuroimaging was normal. MR-spectroscopy (MRS) of the bilateral DLPFC revealed significant for decreased levels of N-acetylaspartate (NAA), glutamate, and glutamate/glutamine ratio. After a follow-up without any medical treatment but with suggestions of memory exercises for three months a control MRS screening of DLPFC showed improved levels of NAA, glutamate, and glutamate/glutamine ratio. This report may suggest that cognitive deficits in SARS-CoV-2 infection can result from glutamatergic dysfunction with decreased NAA and glutamate levels in bilateral DLPFC.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Prefrontal Cortex
/
Aspartic Acid
/
Glutamic Acid
/
Cognitive Dysfunction
/
COVID-19
Type of study:
Case report
/
Cohort study
/
Diagnostic study
/
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
J Clin Neurosci
Journal subject:
Neurology
Year:
2021
Document Type:
Article
Affiliation country:
J.jocn.2021.03.007
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