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Association of Clinical, Biological, and Brain Magnetic Resonance Imaging Findings With Electroencephalographic Findings for Patients With COVID-19.
Lambrecq, Virginie; Hanin, Aurélie; Munoz-Musat, Esteban; Chougar, Lydia; Gassama, Salimata; Delorme, Cécile; Cousyn, Louis; Borden, Alaina; Damiano, Maria; Frazzini, Valerio; Huberfeld, Gilles; Landgraf, Frank; Nguyen-Michel, Vi-Huong; Pichit, Phintip; Sangare, Aude; Chavez, Mario; Morélot-Panzini, Capucine; Morawiec, Elise; Raux, Mathieu; Luyt, Charles-Edouard; Rufat, Pierre; Galanaud, Damien; Corvol, Jean-Christophe; Lubetzki, Catherine; Rohaut, Benjamin; Demeret, Sophie; Pyatigorskaya, Nadya; Naccache, Lionel; Navarro, Vincent.
  • Lambrecq V; Sorbonne Université, Paris Brain Institute, Institut du Cerveau, Institut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Paris, France.
  • Hanin A; Assistance Publique des Hôpitaux de Paris, Clinical Neurophysiology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Munoz-Musat E; Neurophysiology Department, Sorbonne Université, Paris, France.
  • Chougar L; Sorbonne Université, Paris Brain Institute, Institut du Cerveau, Institut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Paris, France.
  • Gassama S; Sorbonne Université, Paris Brain Institute, Institut du Cerveau, Institut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Paris, France.
  • Delorme C; Assistance Publique des Hôpitaux de Paris, Clinical Neurophysiology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Cousyn L; Neurophysiology Department, Sorbonne Université, Paris, France.
  • Borden A; Sorbonne Université, Paris Brain Institute, Institut du Cerveau, Institut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Paris, France.
  • Damiano M; Neuroradiology Department, Sorbonne Université, Paris, France.
  • Frazzini V; Assistance Publique des Hôpitaux de Paris, Neuroradiology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Huberfeld G; Assistance Publique des Hôpitaux de Paris, Neurology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Landgraf F; Assistance Publique des Hôpitaux de Paris, Neurology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Nguyen-Michel VH; Sorbonne Université, Paris Brain Institute, Institut du Cerveau, Institut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Paris, France.
  • Pichit P; Assistance Publique des Hôpitaux de Paris, Neurology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Sangare A; Neurology Department, Sorbonne Université, Paris, France.
  • Chavez M; Assistance Publique des Hôpitaux de Paris, Clinical Neurophysiology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Morélot-Panzini C; Assistance Publique des Hôpitaux de Paris, Clinical Neurophysiology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Morawiec E; Assistance Publique des Hôpitaux de Paris, Neurology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Raux M; Sorbonne Université, Paris Brain Institute, Institut du Cerveau, Institut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Paris, France.
  • Luyt CE; Assistance Publique des Hôpitaux de Paris, Clinical Neurophysiology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Rufat P; Assistance Publique des Hôpitaux de Paris, Neurology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Galanaud D; Assistance Publique des Hôpitaux de Paris, Clinical Neurophysiology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Corvol JC; Neurophysiology Department, Sorbonne Université, Paris, France.
  • Lubetzki C; Assistance Publique des Hôpitaux de Paris, Clinical Neurophysiology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Rohaut B; Assistance Publique des Hôpitaux de Paris, Clinical Neurophysiology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Demeret S; Assistance Publique des Hôpitaux de Paris, Clinical Neurophysiology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Pyatigorskaya N; Assistance Publique des Hôpitaux de Paris, Neurology Department, Pitié-Salpêtrière Hospital, Paris, France.
  • Naccache L; Sorbonne Université, Paris Brain Institute, Institut du Cerveau, Institut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Paris, France.
  • Navarro V; Assistance Publique des Hôpitaux de Paris, Clinical Neurophysiology Department, Pitié-Salpêtrière Hospital, Paris, France.
JAMA Netw Open ; 4(3): e211489, 2021 03 01.
Article in English | MEDLINE | ID: covidwho-1130417
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Patient in hospital PROCESS_OF Adult
Subject
Patient in hospital
Predicate
PROCESS_OF
Object
Adult
3. 2019 novel coronavirus PROCESS_OF Participant
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Participant
4. Hospitals LOCATION_OF Retrospective Cohort Study
Subject
Hospitals
Predicate
LOCATION_OF
Object
Retrospective Cohort Study
5. Chest LOCATION_OF Radionuclide Imaging
Subject
Chest
Predicate
LOCATION_OF
Object
Radionuclide Imaging
6. Electroencephalography ADMINISTERED_TO Patients
Subject
Electroencephalography
Predicate
ADMINISTERED_TO
Object
Patients
7. intensive care unit LOCATION_OF Electroencephalography
Subject
intensive care unit
Predicate
LOCATION_OF
Object
Electroencephalography
8. Brain LOCATION_OF Magnetic Resonance Imaging
Subject
Brain
Predicate
LOCATION_OF
Object
Magnetic Resonance Imaging
9. Magnetic Resonance Imaging ADMINISTERED_TO Patients
Subject
Magnetic Resonance Imaging
Predicate
ADMINISTERED_TO
Object
Patients
10. Movement Disorders PROCESS_OF Patients
Subject
Movement Disorders
Predicate
PROCESS_OF
Object
Patients
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
12. Patient in hospital PROCESS_OF Adult
Subject
Patient in hospital
Predicate
PROCESS_OF
Object
Adult
13. 2019 novel coronavirus PROCESS_OF Participant
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Participant
14. Hospitals LOCATION_OF Retrospective Cohort Study
Subject
Hospitals
Predicate
LOCATION_OF
Object
Retrospective Cohort Study
15. Chest LOCATION_OF Radionuclide Imaging
Subject
Chest
Predicate
LOCATION_OF
Object
Radionuclide Imaging
16. Electroencephalography ADMINISTERED_TO Patients
Subject
Electroencephalography
Predicate
ADMINISTERED_TO
Object
Patients
17. intensive care unit LOCATION_OF Electroencephalography
Subject
intensive care unit
Predicate
LOCATION_OF
Object
Electroencephalography
18. Brain LOCATION_OF Magnetic Resonance Imaging
Subject
Brain
Predicate
LOCATION_OF
Object
Magnetic Resonance Imaging
19. Magnetic Resonance Imaging ADMINISTERED_TO Patients
Subject
Magnetic Resonance Imaging
Predicate
ADMINISTERED_TO
Object
Patients
20. Movement Disorders PROCESS_OF Patients
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Movement Disorders
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PROCESS_OF
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Patients
ABSTRACT
Importance There is evidence of central nervous system impairments associated with coronavirus disease 2019 (COVID-19) infection, including encephalopathy. Multimodal monitoring of patients with COVID-19 may delineate the specific features of COVID-19-related encephalopathy and guide clinical management.

Objectives:

To investigate clinical, biological, and brain magnetic resonance imaging (MRI) findings in association with electroencephalographic (EEG) features for patients with COVID-19, and to better refine the features of COVID-19-related encephalopathy. Design, Setting, and

Participants:

This retrospective cohort study conducted in Pitié-Salpêtrière Hospital, Paris, France, enrolled 78 hospitalized adults who received a diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) and underwent EEG between March 30 and June 11, 2020. Exposures Detection of SARS-CoV-2 from a nasopharyngeal specimen using a reverse transcription-polymerase chain reaction assay or, in the case of associated pneumonia, on a computed tomography scan of the chest. Main Outcomes and

Measures:

Data on the clinical and paraclinical features of the 78 patients with COVID-19 were retrieved from electronic patient records.

Results:

Of 644 patients who were hospitalized for COVID-19, 78 (57 men [73%]; mean [SD] age, 61 [12] years) underwent EEG. The main indications for EEG were delirium, seizure-like events, and delayed awakening in the intensive care unit after stopping treatment with sedatives. Sixty-nine patients showed pathologic EEG findings, including metabolic-toxic encephalopathy features, frontal abnormalities, periodic discharges, and epileptic activities. Of 57 patients who underwent brain MRI, 41 showed abnormalities, including perfusion abnormalities, acute ischemic lesions, multiple microhemorrhages, and white matter-enhancing lesions. Fifty-five patients showed biological abnormalities, including dysnatremia, kidney failure, and liver dysfunction, the same day as the EEG. The results of cerebrospinal fluid analysis were negative for SARS-Cov-2 for all tested patients. Nine patients who had no identifiable cause of brain injury outside COVID-19 were further isolated; their brain injury was defined as COVID-19-related encephalopathy. They represented 1% (9 of 644) of patients with COVID-19 requiring hospitalization. Six of these 9 patients had movement disorders, 7 had frontal syndrome, 4 had brainstem impairment, 4 had periodic EEG discharges, and 3 had MRI white matter-enhancing lesions. Conclusions and Relevance The results from this cohort of patients hospitalized with COVID-19 suggest there are clinical, EEG, and MRI patterns that could delineate specific COVID-19-related encephalopathy and guide treatment strategy.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Diseases / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Language: English Journal: JAMA Netw Open Year: 2021 Document Type: Article Affiliation country: Jamanetworkopen.2021.1489

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Diseases / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Language: English Journal: JAMA Netw Open Year: 2021 Document Type: Article Affiliation country: Jamanetworkopen.2021.1489