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In the eye of the storm: SARS-CoV-2 infection and replication at the ocular surface?
Armstrong, Lyle; Collin, Joseph; Mostafa, Islam; Queen, Rachel; Figueiredo, Francisco C; Lako, Majlinda.
  • Armstrong L; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
  • Collin J; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
  • Mostafa I; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
  • Queen R; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
  • Figueiredo FC; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
  • Lako M; Department of Ophthalmology, Royal Victoria Infirmary and Newcastle University, Newcastle, UK.
Stem Cells Transl Med ; 10(7): 976-986, 2021 07.
Article in English | MEDLINE | ID: covidwho-1130680
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged in December 2019 and spread quickly causing the coronavirus disease 2019 (COVID-19) pandemic. Recent single cell RNA-Seq analyses have shown the presence of SARS-CoV-2 entry factors in the human corneal, limbal, and conjunctival superficial epithelium, leading to suggestions that the human ocular surface may serve as an additional entry gateway and infection hub for SARS-CoV-2. In this article, we review the ocular clinical presentations of COVID-19 and the features of the ocular surface that may underline the overall low ocular SARS-CoV-2 infection. We critically evaluate the studies performed in nonhuman primates, ex vivo organ culture ocular models, stem cell derived eye organoids and the differences in infection efficiency observed in different parts of human ocular surface epithelium. Finally, we highlight the additional work that needs to be carried out to understand the immune response of the ocular surface to SARS-CoV-2 infection, which can be translated into prophylactic treatments that may be applied to other organ systems.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Conjunctiva / Cornea / Eye Diseases / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Stem Cells Transl Med Year: 2021 Document Type: Article Affiliation country: Sctm.20-0543

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Conjunctiva / Cornea / Eye Diseases / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Stem Cells Transl Med Year: 2021 Document Type: Article Affiliation country: Sctm.20-0543