Acute pancreatitis in COVID-19 patients: true risk?
Scand J Gastroenterol
; 56(5): 585-587, 2021 05.
Article
in English
| MEDLINE | ID: covidwho-1132187
ABSTRACT
BACKGROUND:
A relation between coronavirus disease 2019 (COVID-19) and acute pancreatitis has been suggested. However, the incidence and clinical relevance of this relation remain unclear.OBJECTIVE:
We aimed to investigate the incidence, severity and clinical impact of acute pancreatitis in patients with COVID-19.METHODS:
This is a cross-sectional study of a prospective, observational cohort concerning all COVID-19 patients admitted to two Dutch university hospitals between 4 March 2020 and 26 May 2020. Primary outcome was acute pancreatitis potentially related to COVD-19 infection. Acute pancreatitis was defined according to the revised Atlanta Classification. Potential relation with COVID-19 was defined as the absence of a clear aetiology of acute pancreatitis.RESULTS:
Among 433 patients with COVID-19, five (1.2%) had potentially related acute pancreatitis according to the revised Atlanta Classification. These five patients suffered from severe COVID-19 infection; all had (multiple) organ failure and 60% died. None of the patients developed necrotizing pancreatitis. Moreover, development of acute pancreatitis did not lead to major treatment consequences.CONCLUSIONS:
In contrast with previous research, our study demonstrated that COVID-19 related acute pancreatitis is rare and of little clinical impact. It is therefore debatable if acute pancreatitis in COVID-19 patients requires specific screening. We hypothesize that acute pancreatitis occurs in patients with severe illness due to COVID-19 infection as a result of transient hypoperfusion and pancreatic ischemia, not as a direct result of the virus.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pancreas
/
Pancreatitis
/
COVID-19
/
Multiple Organ Failure
Type of study:
Cohort study
/
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
English
Journal:
Scand J Gastroenterol
Year:
2021
Document Type:
Article
Affiliation country:
00365521.2021.1896776
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