Research Progress of Mesenchymal Stem Cell Therapy for Severe COVID-19.
Stem Cells Dev
; 30(9): 459-472, 2021 05 01.
Article
in English
| MEDLINE | ID: covidwho-1132412
ABSTRACT
Corona virus disease 2019 (COVID-19) refers to a type of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Sixty million confirmed cases have been reported worldwide until November 29, 2020. Unfortunately, the novel coronavirus is extremely contagious and the mortality rate of severe and critically ill patients is high. Thus, there is no definite and effective treatment in clinical practice except for antiviral therapy and supportive therapy. Mesenchymal stem cells (MSCs) are not only characterized by low immunogenicity and homing but also have anti-inflammatory and immunomodulation characteristics. Furthermore, they can inhibit the occurrence and development of a cytokine storm, inhibit lung injury, and exert antipulmonary fibrosis and antioxidative stress, therefore MSC therapy is expected to become one of the effective therapies to treat severe COVID-19. This article will review the possible mechanisms of MSCs in the treatment of severe COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pulmonary Fibrosis
/
Mesenchymal Stem Cell Transplantation
/
Lung Injury
/
Cytokine Release Syndrome
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Stem Cells Dev
Journal subject:
Hematology
Year:
2021
Document Type:
Article
Affiliation country:
Scd.2020.0198
Similar
MEDLINE
...
LILACS
LIS