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Pandemic aspect of dexamethasone: Molecular mechanisms and clinical application.
Li, Anna F Y; Wang, Chia-Lin; Tai, Hsiao-Yun; Fu, Yun-Ju; Tsai, Fu-Ting; Tsai, Yi-Ching; Ko, Yu-Ling; Li, Mei-Jane; Lin, Chiou-Chyn; Chang, Tai-Jay.
  • Li AFY; Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
  • Wang CL; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
  • Tai HY; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
  • Fu YJ; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
  • Tsai FT; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
  • Tsai YC; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
  • Ko YL; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
  • Li MJ; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
  • Lin CC; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
  • Chang TJ; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
J Chin Med Assoc ; 84(3): 245-247, 2021 03 01.
Article in English | MEDLINE | ID: covidwho-1132635
ABSTRACT
The rapid spread of coronavirus disease (COVID-19) in many countries has caused inconvenience in conducting daily life activities, and even deaths. Dexamethasone is a corticosteroid applied in clinical medicine since 1957, especially in immune therapy fields. Herein, we present the characteristics of Dexamethasone, from molecular mechanisms such as genomic and nongenomic pathways by cellular signal regulations, to clinical applications in various phases of the disease. During COVID-19 pandemic, Dexamethasone given to patients who required oxygen or ventilation therapy showed improved life efficacy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dexamethasone / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: J Chin Med Assoc Journal subject: Medicine Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dexamethasone / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: J Chin Med Assoc Journal subject: Medicine Year: 2021 Document Type: Article