The Effect of Helicobacter pylori on the Presentation and Clinical Course of Coronavirus Disease 2019 Infection.
J Pediatr Gastroenterol Nutr
; 72(4): 511-513, 2021 04 01.
Article
in English
| MEDLINE | ID: covidwho-1132657
ABSTRACT
OBJECTIVES:
Novel coronavirus 2019 (corona virus disease 2019 [COVID-19]) binds angiotensin-converting enzyme-2 (ACE-2) receptors to enter the cell. These receptors are widely expressed in the intestine, and COVID-19 may cause gastrointestinal symptoms via these receptors during the course of the disease. Helicobacter pylori is known to increase the expression of ACE-2 receptors in the gastrointestinal tract. The aim of this study was to investigate the effects of H pylori on the presentation and clinical course of COVID-19 infections.METHODS:
This study was carried out from June 1 to July 20, 2020. Patients diagnosed with COVID-19 infections by PCR tests were included in the study. Antigen screening tests were performed on stool samples to determine the presence of H pylori. All patients were evaluated for manifestations of COVID-19 infection, severity of the course, hospitalized days because of the virus and outcome of the disease process.RESULTS:
Of 108 COVID-19 positive patients evaluated, 31 with a mean age of 49.54â±â17.94 years were H pylori-positive (8 girls [25.8%]) and 77 with a mean age of 47.85â±â20.51 years; (31 girls [40.3%]) were H pylori-negative. Abdominal pain (19.4% vs 2.6%) and diarrhea (32.3% vs 9.1%) were significantly higher in patients with H pylori than those without (Pâ=â0.007 and Pâ=â0.006, respectively). There was no statistically significant difference between H pylori positivity and the number of hospitalized days, the severity of the course of COVID-19 infection, or the outcome of the disease (Pâ>â0.05).CONCLUSION:
Our results revealed that the findings of abdominal pain and diarrhea strongly correlated with the presence of H pylori in COVID-19 patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Abdominal Pain
/
Helicobacter pylori
/
Helicobacter Infections
/
Diarrhea
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
J Pediatr Gastroenterol Nutr
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS