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The Effects of opioids on female fertility, pregnancy and the breastfeeding mother-infant dyad: A Review.
Corsi, Daniel J; Murphy, Malia S Q.
  • Corsi DJ; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.
  • Murphy MSQ; Better Outcomes Registry & Network (BORN) Ontario, Ottawa, Canada.
Basic Clin Pharmacol Toxicol ; 128(5): 635-641, 2021 May.
Article in English | MEDLINE | ID: covidwho-1132864
Semantic information from SemMedBD (by NLM)
1. Analgesic AFFECTS C1955260
Subject
Analgesic
Predicate
AFFECTS
Object
C1955260
2. Synthetic Drugs INTERACTS_WITH Opioid Receptor
Subject
Synthetic Drugs
Predicate
INTERACTS_WITH
Object
Opioid Receptor
3. Synthetic Drugs CAUSES analgesic effect
Subject
Synthetic Drugs
Predicate
CAUSES
Object
analgesic effect
4. opioid use PROCESS_OF Woman
Subject
opioid use
Predicate
PROCESS_OF
Object
Woman
5. Exploration procedure AFFECTS Fertility
Subject
Exploration procedure
Predicate
AFFECTS
Object
Fertility
6. Analgesics, Opioid AFFECTS Female fertility
Subject
Analgesics, Opioid
Predicate
AFFECTS
Object
Female fertility
7. Synthetic Drugs INTERACTS_WITH Opioid Receptor
Subject
Synthetic Drugs
Predicate
INTERACTS_WITH
Object
Opioid Receptor
8. Synthetic Drugs CAUSES analgesic effect
Subject
Synthetic Drugs
Predicate
CAUSES
Object
analgesic effect
9. opioid use PROCESS_OF Woman
Subject
opioid use
Predicate
PROCESS_OF
Object
Woman
10. Exploration procedure AFFECTS Fertility
Subject
Exploration procedure
Predicate
AFFECTS
Object
Fertility
ABSTRACT
Opioids cover a broad class of natural, synthetic and semi-synthetic drugs that act on opioid receptors to produce powerful analgesic effects. Rates of opioid use and opioid agonist maintenance treatment have increased substantially in recent years, particularly among women. Trends and outcomes of opioids use on fertility, pregnancy and breastfeeding, and longer-term child developmental outcomes have not been well-described. Here, we review the existing literature on the health effects of opioid use on female fertility, pregnancy, breastmilk and the exposed infant. We find that the current literature is primarily concentrated on the impact of opioid use in pregnancy and neonatal outcomes, with little exploration of effects on fertility. Studies are limited in number, some with small sample sizes, and many are hampered by methodological challenges related to confounding and other potential biases. Opioid use is becoming more prevalent due to environmental pressures such as COVID-19. More research is needed to better elucidate its effects on reproductive health among younger women and support the development of evidence-based recommendations for safe prescription practices and public health messaging.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications / Practice Patterns, Physicians' / Breast Feeding / Fertility / Opioid-Related Disorders Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Basic Clin Pharmacol Toxicol Journal subject: Pharmacology / Toxicology Year: 2021 Document Type: Article Affiliation country: Bcpt.13577

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications / Practice Patterns, Physicians' / Breast Feeding / Fertility / Opioid-Related Disorders Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Basic Clin Pharmacol Toxicol Journal subject: Pharmacology / Toxicology Year: 2021 Document Type: Article Affiliation country: Bcpt.13577