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Severe acute respiratory syndrome coronavirus 2 prevalence in saliva and gastric and intestinal fluid in patients undergoing gastrointestinal endoscopy in coronavirus disease 2019 endemic areas: Prospective cross-sectional study in Japan.
Miyake, Shigeta; Ashikari, Keiichi; Kato, Shingo; Takatsu, Tomohiro; Kuwashima, Hirofumi; Kaneko, Hiroaki; Nagai, Koki; Watari, Ikue; Sato, Takamitsu; Yamaoka, Yutaro; Yamamoto, Tetsuya; Ryo, Akihide; Maeda, Shin; Nakajima, Atsushi; Higurashi, Takuma.
  • Miyake S; Department of, Neurosurgery, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan.
  • Ashikari K; Department of, Gastroenterology and Hepatology, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan.
  • Kato S; Department of, Gastroenterology and Hepatology, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan.
  • Takatsu T; Department of, Clinical Cancer Genomics, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan.
  • Kuwashima H; Department of, Gastroenterology and Hepatology, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan.
  • Kaneko H; Department of, Gastroenterology, Yokohama City University, Kanagawa, Japan.
  • Nagai K; Department of, Gastroenterology, Yokohama City University, Kanagawa, Japan.
  • Watari I; Department of, Gastroenterology and Hepatology, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan.
  • Sato T; Department of, Gastroenterology and Hepatology, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan.
  • Yamaoka Y; Department of, Gastroenterology and Hepatology, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan.
  • Yamamoto T; Department of Microbiology, School of Medicine, Yokohama City University, Kanagawa, Japan.
  • Ryo A; Life Science Laboratory, Technology and Development Division, Kanto Chemical Co., Inc., Kanagawa, Japan.
  • Maeda S; Department of, Neurosurgery, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan.
  • Nakajima A; Department of Microbiology, School of Medicine, Yokohama City University, Kanagawa, Japan.
  • Higurashi T; Department of, Gastroenterology, Yokohama City University, Kanagawa, Japan.
Dig Endosc ; 2021 Feb 06.
Article in English | MEDLINE | ID: covidwho-1132881
Semantic information from SemMedBD (by NLM)
1. Body Fluids PART_OF Intestines
Subject
Body Fluids
Predicate
PART_OF
Object
Intestines
2. Endoscop TREATS C0030705
Subject
Endoscop
Predicate
TREATS
Object
C0030705
3. Patients LOCATION_OF Body Fluids
Subject
Patients
Predicate
LOCATION_OF
Object
Body Fluids
4. Patients LOCATION_OF saliva
Subject
Patients
Predicate
LOCATION_OF
Object
saliva
5. Interventional procedure TREATS Disease
Subject
Interventional procedure
Predicate
TREATS
Object
Disease
6. 2019 novel coronavirus PROCESS_OF Patients
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Patients
7. Body Fluids PART_OF Intestines
Subject
Body Fluids
Predicate
PART_OF
Object
Intestines
8. Endoscopy, Gastrointestinal TREATS Patients
Subject
Endoscopy, Gastrointestinal
Predicate
TREATS
Object
Patients
9. Patients LOCATION_OF Body Fluids
Subject
Patients
Predicate
LOCATION_OF
Object
Body Fluids
10. Patients LOCATION_OF saliva
Subject
Patients
Predicate
LOCATION_OF
Object
saliva
11. Interventional procedure TREATS Disease
Subject
Interventional procedure
Predicate
TREATS
Object
Disease
12. 2019 novel coronavirus PROCESS_OF Patients
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

OBJECTIVES:

Gastrointestinal endoscopy (GIE) is useful for the early detection and treatment of many diseases; however, GIE is considered a high-risk procedure in the coronavirus disease 2019 (COVID-19) pandemic era. This study aimed to explore the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity in saliva and gastrointestinal fluids to which endoscopy medical staff are exposed.

METHODS:

The study was a single-center cross-sectional study. From June 1 to July 31, 2020, all patients who underwent GIE at Yokohama City University Hospital were registered. All patients provided 3 mL of saliva. For upper GIE, 10 mL of gastric fluid was collected through the endoscope. For lower GIE, 10 mL of intestinal fluid was collected through the endoscope. The primary outcome was the positive rate of SARS-CoV-2 in saliva and gastrointestinal fluids. We also analyzed serum-specific antibodies for SARS-CoV-2 and patients' background information.

RESULTS:

A total of 783 samples (560 upper GIE and 223 lower GIE samples) were analyzed. Polymerase chain reaction (PCR) on saliva samples did not show any positive results in either upper or lower GIE samples. However, 2.0% (16/783) of gastrointestinal fluid samples tested positive for SARS-CoV-2. No significant differences in age, sex, purpose of endoscopy, medication, or rate of antibody test positivity were found between PCR positive and PCR negative cases.

CONCLUSIONS:

Asymptomatic patients, even those with no detectable virus in their saliva, had SARS-CoV-2 in their gastrointestinal tract. Endoscopy medical staff should be aware of infection when performing procedures. The study was registered as UMIN000040587.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Observational study / Prevalence study / Risk factors / Screening study Language: English Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Observational study / Prevalence study / Risk factors / Screening study Language: English Clinical aspect: Etiology Year: 2021
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