Your browser doesn't support javascript.
Prolonged fever and hyperferritinaemia: a puzzling diagnosis of neonatal herpes simplex virus infection during COVID-19 pandemic.
Badawy, Mohammed Kamal; Hurrell, Sophie; Baldwin, Catherine; Hassan, Heba.
  • Badawy MK; Paediatrics, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, Essex, UK mohammed.badawy@doctors.net.uk.
  • Hurrell S; Paediatrics, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, Essex, UK.
  • Baldwin C; Paediatrics, East and North Hertfordshire NHS Trust, Stevenage, UK.
  • Hassan H; Paediatrics, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, Essex, UK.
BMJ Case Rep ; 14(3)2021 Mar 10.
Article in English | MEDLINE | ID: covidwho-1133189
Semantic information from SemMedBD (by NLM)
1. Neonatal herpes COEXISTS_WITH COVID-19
Subject
Neonatal herpes
Predicate
COEXISTS_WITH
Object
COVID-19
2. estrogen receptor alph ASSOCIATED_WITH C0476474
Subject
estrogen receptor alph
Predicate
ASSOCIATED_WITH
Object
C0476474
3. estrogen receptor alph PART_OF C4551581
Subject
estrogen receptor alph
Predicate
PART_OF
Object
C4551581
4. persistent fever PROCESS_OF Term Infant
Subject
persistent fever
Predicate
PROCESS_OF
Object
Term Infant
5. Increased ferritin PROCESS_OF Term Infant
Subject
Increased ferritin
Predicate
PROCESS_OF
Object
Term Infant
6. estrogen receptor alph PART_OF C5203676
Subject
estrogen receptor alph
Predicate
PART_OF
Object
C5203676
7. acyclovir TREATS Full recovery
Subject
acyclovir
Predicate
TREATS
Object
Full recovery
8. Fever PROCESS_OF Infan
Subject
Fever
Predicate
PROCESS_OF
Object
Infan
9. Hyperferritinemia COEXISTS_WITH Negative
Subject
Hyperferritinemia
Predicate
COEXISTS_WITH
Object
Negative
10. Hyperferritinemia COEXISTS_WITH maternal history
Subject
Hyperferritinemia
Predicate
COEXISTS_WITH
Object
maternal history
11. Herpes Simplex Infections PROCESS_OF Infan
Subject
Herpes Simplex Infections
Predicate
PROCESS_OF
Object
Infan
12. Challenge:Type:Point in time:^Patient:Nominal PREDISPOSES COVID-19
Subject
Challenge:Type:Point in time:^Patient:Nominal
Predicate
PREDISPOSES
Object
COVID-19
13. COVID-19 PROCESS_OF Infan
Subject
COVID-19
Predicate
PROCESS_OF
Object
Infan
14. Neonatal herpes COEXISTS_WITH COVID-19
Subject
Neonatal herpes
Predicate
COEXISTS_WITH
Object
COVID-19
15. estrogen receptor alpha, human ASSOCIATED_WITH persistent fever
Subject
estrogen receptor alpha, human
Predicate
ASSOCIATED_WITH
Object
persistent fever
16. estrogen receptor alpha, human PART_OF Term Infant
Subject
estrogen receptor alpha, human
Predicate
PART_OF
Object
Term Infant
17. persistent fever PROCESS_OF Term Infant
Subject
persistent fever
Predicate
PROCESS_OF
Object
Term Infant
18. Increased ferritin PROCESS_OF Term Infant
Subject
Increased ferritin
Predicate
PROCESS_OF
Object
Term Infant
19. estrogen receptor alpha, human PART_OF 2019 novel coronavirus
Subject
estrogen receptor alpha, human
Predicate
PART_OF
Object
2019 novel coronavirus
20. acyclovir TREATS Full recovery
Subject
acyclovir
Predicate
TREATS
Object
Full recovery
21. Fever PROCESS_OF Infant, Newborn
Subject
Fever
Predicate
PROCESS_OF
Object
Infant, Newborn
22. Hyperferritinemia COEXISTS_WITH Negative
Subject
Hyperferritinemia
Predicate
COEXISTS_WITH
Object
Negative
23. Hyperferritinemia COEXISTS_WITH maternal history
Subject
Hyperferritinemia
Predicate
COEXISTS_WITH
Object
maternal history
24. Herpes Simplex Infections PROCESS_OF Infant, Newborn
Subject
Herpes Simplex Infections
Predicate
PROCESS_OF
Object
Infant, Newborn
25. Challenge:Type:Point in time:^Patient:Nominal PREDISPOSES COVID-19
Subject
Challenge:Type:Point in time:^Patient:Nominal
Predicate
PREDISPOSES
Object
COVID-19
26. COVID-19 PROCESS_OF Infant, Newborn
Subject
COVID-19
Predicate
PROCESS_OF
Object
Infant, Newborn
ABSTRACT
Neonatal herpes simplex virus (HSV) infection is rare, with an estimated incidence of 3.58 per 100 000 live births in the UK and should be suspected in any newborn with fever and bacterial culture-negative sepsis. We describe a case of a previously well full-term male neonate who presented with persistent fever and elevated ferritin level that was carried out during the era of the COVID-19 pandemic as part of SARS-CoV-2 panel investigations. Despite the initial negative HSV serology, HSV-1 PCR from a scalp lesion returned positive. He made a full recovery after acyclovir therapy. This case highlights the importance of maintaining a high clinical index of suspicion of HSV infection in any febrile neonate even with absence of maternal history and negative serology, particularly if associated with hyperferritinaemia. We also address the challenge of interpreting inflammatory biomarkers' results for SARS-CoV-2 infection in neonates.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Ferritins / Fever / COVID-19 / Herpes Simplex Type of study: Diagnostic study Limits: Female / Humans / Male / Infant, Newborn / Pregnancy Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2020-241405

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Ferritins / Fever / COVID-19 / Herpes Simplex Type of study: Diagnostic study Limits: Female / Humans / Male / Infant, Newborn / Pregnancy Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2020-241405