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Optic nerve and macular optical coherence tomography in recovered COVID-19 patients.
Burgos-Blasco, Barbara; Güemes-Villahoz, Noemi; Vidal-Villegas, Beatriz; Martinez-de-la-Casa, Jose Maria; Donate-Lopez, Juan; Martín-Sánchez, Francisco Javier; González-Armengol, Juan Jorge; Porta-Etessam, Jesus; Martin, Jose Luis R; Garcia-Feijoo, Julian.
  • Burgos-Blasco B; Ophthalmology Department, Hospital Clínico San Carlos, Madrid, Spain.
  • Güemes-Villahoz N; Ophthalmology Department, Hospital Clínico San Carlos, Madrid, Spain.
  • Vidal-Villegas B; Ophthalmology Department, Hospital Clínico San Carlos, Madrid, Spain.
  • Martinez-de-la-Casa JM; Ophthalmology Department, Hospital Clínico San Carlos, Madrid, Spain.
  • Donate-Lopez J; Ophthalmology Department, Hospital Clínico San Carlos, Madrid, Spain.
  • Martín-Sánchez FJ; Emergency Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdiSCC), Universidad Complutense de Madrid, Spain.
  • González-Armengol JJ; Emergency Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdiSCC), Universidad Complutense de Madrid, Spain.
  • Porta-Etessam J; Neurology Department, Hospital Clínico San Carlos, Madrid, Spain.
  • Martin JLR; Simplifying Research Institute, Madrid, Spain.
  • Garcia-Feijoo J; Ophthalmology Department, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IsISSC), IIORC, Universidad Complutense, Madrid, Spain.
Eur J Ophthalmol ; 32(1): 628-636, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1133564
ABSTRACT

PURPOSE:

To investigate the peripapillary retinal nerve fiber layer thickness (RNFLT), macular RNFLT, ganglion cell layer (GCL), and inner plexiform layer (IPL) thickness in recovered COVID-19 patients compared to controls.

METHODS:

Patients previously diagnosed with COVID-19 were included, while healthy patients formed the historic control group. All patients underwent an ophthalmological examination, including macular and optic nerve optical coherence tomography. In the case group, socio-demographic data, medical history, and neurological symptoms were collected.

RESULTS:

One hundred sixty patients were included; 90 recovered COVID-19 patients and 70 controls. COVID-19 patients presented increases in global RNFLT (mean difference 4.3; CI95% 0.8 to 7.7), nasal superior (mean difference 6.9; CI95% 0.4 to 13.4), and nasal inferior (mean difference 10.2; CI95% 2.4 to 18.1) sectors of peripapillary RNFLT. Macular RNFL showed decreases in COVID-19 patients in volume (mean difference -0.05; CI95% -0.08 to -0.02), superior inner (mean difference -1.4; CI95% -2.5 to -0.4), nasal inner (mean difference -1.1; CI95% -1.8 to -0.3), and nasal outer (mean difference -4.7; CI95% -7.0 to -2.4) quadrants. COVID-19 patients presented increased GCL thickness in volume (mean difference 0.04; CI95% 0.01 to 0.07), superior outer (mean difference 2.1; CI95% 0.8 to 3.3), nasal outer (mean difference 2.5; CI95% 1.1 to 4.0), and inferior outer (mean difference1.2; CI95% 0.1 to 2.4) quadrants. COVID-19 patients with anosmia and ageusia presented an increase in peripapillary RNFLT and macular GCL compared to patients without these symptoms.

CONCLUSIONS:

SARS-CoV-2 may affect the optic nerve and cause changes in the retinal layers once the infection has resolved.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tomography, Optical Coherence / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Eur J Ophthalmol Journal subject: Ophthalmology Year: 2022 Document Type: Article Affiliation country: 11206721211001019

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tomography, Optical Coherence / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Eur J Ophthalmol Journal subject: Ophthalmology Year: 2022 Document Type: Article Affiliation country: 11206721211001019