Self-proning in COVID-19 patients on low-flow oxygen therapy: a cluster randomised controlled trial.
ERJ Open Res
; 7(1)2021 Jan.
Article
in English
| MEDLINE | ID: covidwho-1133579
ABSTRACT
RATIONALE AND OBJECTIVES:
Prone positioning as a complement to oxygen therapy to treat hypoxaemia in coronavirus disease 2019 (COVID-19) pneumonia in spontaneously breathing patients has been widely adopted, despite a lack of evidence for its benefit. We tested the hypothesis that a simple incentive to self-prone for a maximum of 12â h per day would decrease oxygen needs in patients admitted to the ward for COVID-19 pneumonia on low-flow oxygen therapy.METHODS:
27 patients with confirmed COVID-19 pneumonia admitted to Geneva University Hospitals were included in the study. 10 patients were randomised to self-prone positioning and 17 to usual care. MEASUREMENTS AND MAINRESULTS:
Oxygen needs assessed by oxygen flow on nasal cannula at inclusion were similar between groups. 24â h after starting the intervention, the median (interquartile range (IQR)) oxygen flow was 1.0 (0.1-2.9)â L·min-1 in the prone position group and 2.0 (0.5-3.0)â L·min-1 in the control group (p=0.507). Median (IQR) oxygen saturation/fraction of inspired oxygen ratio was 390 (300-432) in the prone position group and 336 (294-422) in the control group (p=0.633). One patient from the intervention group who did not self-prone was transferred to the high-dependency unit. Self-prone positioning was easy to implement. The intervention was well tolerated and only mild side-effects were reported.CONCLUSIONS:
Self-prone positioning in patients with COVID-19 pneumonia requiring low-flow oxygen therapy resulted in a clinically meaningful reduction of oxygen flow, but without reaching statistical significance.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
23120541.00692-2020
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