Your browser doesn't support javascript.
COVID-19 Impairs Immune Response to Candida albicans.
Moser, Dominique; Biere, Katharina; Han, Bing; Hoerl, Marion; Schelling, Gustav; Choukér, Alexander; Woehrle, Tobias.
  • Moser D; Department of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
  • Biere K; Department of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
  • Han B; Department of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
  • Hoerl M; Department of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
  • Schelling G; Department of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
  • Choukér A; Department of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
  • Woehrle T; Department of Anesthesiology, LMU Hospital, Ludwig-Maximilians-University, Munich, Germany.
Front Immunol ; 12: 640644, 2021.
Article in English | MEDLINE | ID: covidwho-1133916
Semantic information from SemMedBD (by NLM)
1. COVID-19 COEXISTS_WITH Severe Acute Respiratory Syndrome
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Severe Acute Respiratory Syndrome
2. Coinfection COEXISTS_WITH COVID-19
Subject
Coinfection
Predicate
COEXISTS_WITH
Object
COVID-19
3. Plasma LOCATION_OF cytokine
Subject
Plasma
Predicate
LOCATION_OF
Object
cytokine
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
5. Respiratory Distress Syndrom PROCESS_OF C0030705
Subject
Respiratory Distress Syndrom
Predicate
PROCESS_OF
Object
C0030705
6. Secondary Infections AFFECTS Immune
Subject
Secondary Infections
Predicate
AFFECTS
Object
Immune
7. TNF STIMULATES Aspergillus fumigatus antigen
Subject
TNF
Predicate
STIMULATES
Object
Aspergillus fumigatus antigen
8. interleukin- STIMULATES C0450095
Subject
interleukin-
Predicate
STIMULATES
Object
C0450095
9. interleukin-6 STIMULATES Aspergillus fumigatus antigen
Subject
interleukin-6
Predicate
STIMULATES
Object
Aspergillus fumigatus antigen
10. IL1A protei STIMULATES C0450095
Subject
IL1A protei
Predicate
STIMULATES
Object
C0450095
11. Immune response PROCESS_OF Patients
Subject
Immune response
Predicate
PROCESS_OF
Object
Patients
12. COVID-19 COEXISTS_WITH Severe Acute Respiratory Syndrome
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Severe Acute Respiratory Syndrome
13. Coinfection COEXISTS_WITH COVID-19
Subject
Coinfection
Predicate
COEXISTS_WITH
Object
COVID-19
14. Plasma LOCATION_OF cytokine
Subject
Plasma
Predicate
LOCATION_OF
Object
cytokine
15. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
16. Respiratory Distress Syndrome, Adult PROCESS_OF Patients
Subject
Respiratory Distress Syndrome, Adult
Predicate
PROCESS_OF
Object
Patients
17. Secondary Infections AFFECTS Immune
Subject
Secondary Infections
Predicate
AFFECTS
Object
Immune
18. TNF STIMULATES Aspergillus fumigatus antigen
Subject
TNF
Predicate
STIMULATES
Object
Aspergillus fumigatus antigen
19. interleukin-1, beta STIMULATES Aspergillus fumigatus antigen
Subject
interleukin-1, beta
Predicate
STIMULATES
Object
Aspergillus fumigatus antigen
20. interleukin-6 STIMULATES Aspergillus fumigatus antigen
Subject
interleukin-6
Predicate
STIMULATES
Object
Aspergillus fumigatus antigen
21. IL1A protein, human|IL1A STIMULATES Aspergillus fumigatus antigen
Subject
IL1A protein, human|IL1A
Predicate
STIMULATES
Object
Aspergillus fumigatus antigen
22. Immune response PROCESS_OF Patients
Subject
Immune response
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Infection with SARS-CoV-2 can lead to Coronavirus disease-2019 (COVID-19) and result in severe acute respiratory distress syndrome (ARDS). Recent reports indicate an increased rate of fungal coinfections during COVID-19. With incomplete understanding of the pathogenesis and without any causative therapy available, secondary infections may be detrimental to the prognosis. We monitored 11 COVID-19 patients with ARDS for their immune phenotype, plasma cytokines, and clinical parameters on the day of ICU admission and on day 4 and day 7 of their ICU stay. Whole blood stimulation assays with lipopolysaccharide (LPS), heat-killed Listeria monocytogenes (HKLM), Aspergillus fumigatus, and Candida albicans were used to mimic secondary infections, and changes in immune phenotype and cytokine release were assessed. COVID-19 patients displayed an immune phenotype characterized by increased HLA-DR+CD38+ and PD-1+ CD4+ and CD8+ T cells, and elevated CD8+CD244+ lymphocytes, compared to healthy controls. Monocyte activation markers and cytokines IL-6, IL-8, TNF, IL-10, and sIL2Rα were elevated, corresponding to monocyte activation syndrome, while IL-1ß levels were low. LPS, HKLM and Aspergillus fumigatus antigen stimulation provoked an immune response that did not differ between COVID-19 patients and healthy controls, while COVID-19 patients showed an attenuated monocyte CD80 upregulation and abrogated release of IL-6, TNF, IL-1α, and IL-1ß toward Candida albicans. This study adds further detail to the characterization of the immune response in critically ill COVID-19 patients and hints at an increased susceptibility for Candida albicans infection.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Aspergillus fumigatus / Candida albicans / CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 / Listeria monocytogenes Subject: Aspergillus fumigatus / Candida albicans / CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 / Listeria monocytogenes Type of study: Prognostic study Language: English Journal: Front Immunol Clinical aspect: Prognosis Year: 2021

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Aspergillus fumigatus / Candida albicans / CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 / Listeria monocytogenes Subject: Aspergillus fumigatus / Candida albicans / CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 / Listeria monocytogenes Type of study: Prognostic study Language: English Journal: Front Immunol Clinical aspect: Prognosis Year: 2021
...