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Persistent Somatic Symptom Burden and Sleep Disturbance in Patients with COVID-19 During Hospitalization and After Discharge: A Prospective Cohort Study.
Huang, Shujie; Zhuang, Weitao; Wang, Dongya; Zha, Lulu; Xu, Xi; Li, Xiangdong; Shi, Qiuling; Wang, Xin Shelley; Qiao, Guibin.
  • Huang S; Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China (mainland).
  • Zhuang W; Shantou University Medical College, Shantou, Guangdong, China (mainland).
  • Wang D; Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China (mainland).
  • Zha L; Shantou University Medical College, Shantou, Guangdong, China (mainland).
  • Xu X; Huoshenshan Hospital, Wuhan, Hubei, China (mainland).
  • Li X; General Hospital of Southern Theater Command, Chinese People's Liberation Army, Guangzhou, Guangdong, China (mainland).
  • Shi Q; Huoshenshan Hospital, Wuhan, Hubei, China (mainland).
  • Wang XS; General Hospital of Southern Theater Command, Chinese People's Liberation Army, Guangzhou, Guangdong, China (mainland).
  • Qiao G; Huoshenshan Hospital, Wuhan, Hubei, China (mainland).
Med Sci Monit ; 27: e930447, 2021 Apr 15.
Article in English | MEDLINE | ID: covidwho-1134483
ABSTRACT
BACKGROUND The present study was designed to reveal the trajectory of self-reported somatic symptom burden and sleep quality over time in patients with COVID-19 and to identify prognostic factors for greater somatic symptom burden and sleep disturbance. MATERIAL AND METHODS Seventy-four patients with COVID-19 were prospectively followed for longitudinal assessment of somatic symptom burden and sleep quality. We used the 8-item Somatic Symptom Scale (SSS-8) and the modified Medical Research Council (mMRC) scale for somatic symptom burden and the Pittsburgh Sleep Quality Index for sleep quality investigation. Univariate and multivariate analyses were performed to identify independent factors associated with somatic symptom burden and sleep quality. RESULTS Although the degree of physical discomfort and sleep quality issues tended to decline during self-quarantine, patients still experienced these problems to a certain degree. Univariate and multivariate analyses showed that SSS-8 scores at admission (relative risk [RR] 1.234, 95% CI 1.075-1.417, P=0.003) and mMRC scores at discharge (RR 2.420, 95% CI 1.251-4.682, P=0.009) were 2 independent prognostic indicators of somatic symptom burden. In addition, muscle pain as a chief complaint (RR 4.682, 95% CI 1.247-17.580, P<0.022) and history of use of hypnotic drugs (RR 0.148, 95% CI 0.029-0.749, P<0.019) were 2 independent indicators of patient sleep quality during hospitalization. CONCLUSIONS To the best of our knowledge, the present study was the first dynamic assessment of the somatic symptom burden and sleep quality in patients with COVID-19 during hospitalization and quarantine after discharge. Patients with high somatic symptom burden at admission, especially muscle pain as the chief complaint, are prone to having a higher physical burden and more sleep disturbance at discharge.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sleep Wake Disorders / Cost of Illness / Myalgia / Medically Unexplained Symptoms / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Med Sci Monit Journal subject: Medicine Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sleep Wake Disorders / Cost of Illness / Myalgia / Medically Unexplained Symptoms / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Med Sci Monit Journal subject: Medicine Year: 2021 Document Type: Article