Your browser doesn't support javascript.
Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense.
Abdalla, Abualgasim Elgaili; Xie, Jianping; Junaid, Kashaf; Younas, Sonia; Elsaman, Tilal; Abosalif, Khalid Omer Abdalla; Alameen, Ayman Ali Mohammed; Mahjoob, Mahjoob Osman; Elamir, Mohammed Yagoub Mohammed; Ejaz, Hasan.
  • Abdalla AE; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia; Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan.
  • Xie J; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing, China
  • Junaid K; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia.
  • Younas S; Department of Pathology, Tehsil Headquarter Hospital Kamoke, District Gujranwala, Kamoke, Pakistan.
  • Elsaman T; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Al Jouf, Saudi Arabia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omdurman Islamic University, Omdurman, Sudan.
  • Abosalif KOA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia; Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan.
  • Alameen AAM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia; Department of Chemical Pathology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
  • Mahjoob MO; Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan.
  • Elamir MYM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia; Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan.
  • Ejaz H; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia.
Bosn J Basic Med Sci ; 21(5): 515-527, 2021 Oct 01.
Article in English | MEDLINE | ID: covidwho-1134549
ABSTRACT
Coronavirus disease-19 (COVID-19) is an extremely infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has become a major global health concern. The induction of a coordinated immune response is crucial to the elimination of any pathogenic infection. However, SARS-CoV-2 can modulate the host immune system to favor viral adaptation and persistence within the host. The virus can counteract type I interferon (IFN-I) production, attenuating IFN-I signaling pathway activation and disrupting antigen presentation. Simultaneously, SARS-CoV-2 infection can enhance apoptosis and the production of inflammatory mediators, which ultimately results in increased disease severity. SARS-CoV-2 produces an array of effector molecules, including nonstructural proteins (NSPs) and open-reading frames (ORFs) accessory proteins. We describe the complex molecular interplay of SARS-CoV-2 NSPs and accessory proteins with the host's signaling mediating immune evasion in the current review. In addition, the crucial role played by immunomodulation therapy to address immune evasion is discussed. Thus, the current review can provide new directions for the development of vaccines and specific therapies.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Nonstructural Proteins / Viral Regulatory and Accessory Proteins / Immune Evasion / SARS-CoV-2 / COVID-19 / Immunity, Innate Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Bosn J Basic Med Sci Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Bjbms.2020.5543

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Nonstructural Proteins / Viral Regulatory and Accessory Proteins / Immune Evasion / SARS-CoV-2 / COVID-19 / Immunity, Innate Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Bosn J Basic Med Sci Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Bjbms.2020.5543