Your browser doesn't support javascript.
Age cohorts stratified according to age-distributions of COVID-19 morbidity statistics identify uniquely age-dependent CD3+CD8+ T-cell lymphocytopenia in COVID-19 patients without comorbidities on admission.
Jin, Shengwei; An, Hui; Zhou, Tong; Li, Ting; Chen, Chengshui; Ying, Binyu; Xu, Zhangye; Li, Xiaokun; Li, Ming.
  • Jin S; School of Basic Medical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • An H; Department of Anesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Zhou T; School of Basic Medical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Li T; Department of Anesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Chen C; School of Basic Medical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Ying B; Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Xu Z; Department of Anesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Li X; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Li M; Department of Critical Care Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Aging (Albany NY) ; 13(6): 7713-7722, 2021 03 10.
Article in English | MEDLINE | ID: covidwho-1134586
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Disease PROCESS_OF Patients
Subject
Disease
Predicate
PROCESS_OF
Object
Patients
3. 2019 novel coronavirus CAUSES Lymphopenia
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
Lymphopenia
4. Human Age Group LOCATION_OF TRIM37 gene|TRIM37
Subject
Human Age Group
Predicate
LOCATION_OF
Object
TRIM37 gene|TRIM37
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Disease PROCESS_OF Patients
Subject
Disease
Predicate
PROCESS_OF
Object
Patients
7. 2019 novel coronavirus CAUSES Lymphopenia
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
Lymphopenia
8. Human Age Group LOCATION_OF TRIM37 gene|TRIM37
Subject
Human Age Group
Predicate
LOCATION_OF
Object
TRIM37 gene|TRIM37
ABSTRACT
If age boundaries are arbitrarily or roughly defined, age-related analyses can result in questionable findings. Here, we aimed to delineate the uniquely age-dependent immune features of coronavirus disease 2019 (COVID-19) in a retrospective study of 447 patients, stratified according to age distributions of COVID-19 morbidity statistics into well-defined age-cohorts (2-25y, 26-38y, 39-57y, 58-68y, and 69-79y). Age-dependent susceptibilities and severities of the disease were observed in COVID-19 patients. A comparison of the lymphocyte counts among the five age-groups indicated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection led to age-dependent lymphopenia. Among the lymphocyte subsets, the CD8+ T cell count alone was significantly and age-dependently decreased (520, 385, 320, 172, and 139 n/µl in the five age-groups, respectively). In contrast, the CD4+ T cell, B cell, and natural killer cell counts did not differ among age-cohorts. Age and CD8+ T cell counts (r=‒0.435, p<0.0001) were negatively correlated in COVID-19 patients. Moreover, SARS-CoV-2 infection age-dependently increased the plasma C-reactive protein concentrations (2.0, 5.0, 9.0, 11.6, and 36.1 mg/L in the five age-groups, respectively). These findings can be used to elucidate the role of CD8+ T cells in age-related pathogenesis and to help develop therapeutic strategies for COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Patient Admission / CD3 Complex / Age Distribution / CD8-Positive T-Lymphocytes / COVID-19 / Lymphopenia Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid / Variants Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2021 Document Type: Article Affiliation country: Aging.202691

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Patient Admission / CD3 Complex / Age Distribution / CD8-Positive T-Lymphocytes / COVID-19 / Lymphopenia Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid / Variants Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2021 Document Type: Article Affiliation country: Aging.202691