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Human Infection Challenge Experiments: Then and Now.
Miller, Franklin G; Moreno, Jonathan D.
  • Miller FG; Professor of medical ethics in medicine at Weill Cornell Medical College.
  • Moreno JD; David and Lyn Silfen University Professor at the University of Pennsylvania.
Ethics Hum Res ; 43(3): 42-44, 2021 May.
Article in English | MEDLINE | ID: covidwho-1135094
ABSTRACT
In the midst of the Covid-19 pandemic, ethicists, researchers, and journalists have recommended studies that deliberately infect healthy volunteers with the coronavirus as a scientific means of expediting vaccine development. In this essay, we trace the history of infection challenge experiments and reflect on the Nuremberg Code of 1947, issued in response to brutal human experiments conducted by Nazi investigators in concentration camps. We argue that the Code continues to offer valuable guidance for assessing the ethics of this controversial form of research, with respect particularly to the acceptable limits to research risks and the social value of research necessary to justify exposing human participants to these risks.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Human Experimentation Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Ethics Hum Res Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Human Experimentation Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Ethics Hum Res Year: 2021 Document Type: Article