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Translational adaptation of human viruses to the tissues they infect.
Hernandez-Alias, Xavier; Benisty, Hannah; Schaefer, Martin H; Serrano, Luis.
  • Hernandez-Alias X; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain. Electronic address: xavier.hernandez@crg.eu.
  • Benisty H; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain.
  • Schaefer MH; IEO European Institute of Oncology IRCCS, Department of Experimental Oncology, Via Adamello 16, Milan 20139, Italy. Electronic address: martin.schaefer@ieo.it.
  • Serrano L; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain; ICREA, Pg. Lluís Companys 23, Barcelona 08010, Spain. Electronic address: luis.serrano@crg.eu.
Cell Rep ; 34(11): 108872, 2021 03 16.
Article in English | MEDLINE | ID: covidwho-1135279
ABSTRACT
Viruses need to hijack the translational machinery of the host cell for a productive infection to happen. However, given the dynamic landscape of tRNA pools among tissues, it is unclear whether different viruses infecting different tissues have adapted their codon usage toward their tropism. Here, we collect the coding sequences of 502 human-infecting viruses and determine that tropism explains changes in codon usage. Using the tRNA abundances across 23 human tissues from The Cancer Genome Atlas (TCGA), we build an in silico model of translational efficiency that validates the correspondence of the viral codon usage with the translational machinery of their tropism. For instance, we detect that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is specifically adapted to the upper respiratory tract and alveoli. Furthermore, this correspondence is specifically defined in early viral proteins. The observed tissue-specific translational efficiency could be useful for the development of antiviral therapies and vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Protein Biosynthesis / Viruses / Virus Diseases Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Cell Rep Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Protein Biosynthesis / Viruses / Virus Diseases Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Cell Rep Year: 2021 Document Type: Article