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Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes.
Pradenas, Edwards; Trinité, Benjamin; Urrea, Víctor; Marfil, Silvia; Ávila-Nieto, Carlos; Rodríguez de la Concepción, María Luisa; Tarrés-Freixas, Ferran; Pérez-Yanes, Silvia; Rovirosa, Carla; Ainsua-Enrich, Erola; Rodon, Jordi; Vergara-Alert, Júlia; Segalés, Joaquim; Guallar, Victor; Valencia, Alfonso; Izquierdo-Useros, Nuria; Paredes, Roger; Mateu, Lourdes; Chamorro, Anna; Massanella, Marta; Carrillo, Jorge; Clotet, Bonaventura; Blanco, Julià.
  • Pradenas E; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Trinité B; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Urrea V; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Marfil S; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Ávila-Nieto C; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Rodríguez de la Concepción ML; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Tarrés-Freixas F; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Pérez-Yanes S; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Rovirosa C; Laboratorio de Inmunología Celular y Viral, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna (ULL), La Laguna 38071, Tenerife, Spain.
  • Ainsua-Enrich E; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Rodon J; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Vergara-Alert J; IRTA Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Bellaterra, Catalonia, Spain.
  • Segalés J; IRTA Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Bellaterra, Catalonia, Spain.
  • Guallar V; UAB, Centre de Recerca en Sanitat Animal (IRTA-UAB), Campus de la UAB, 08193 Bellaterra, Catalonia, Spain.
  • Valencia A; Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Bellaterra, Catalonia, Spain.
  • Izquierdo-Useros N; Barcelona Supercomputing Center, 08034 Barcelona, Catalonia, Spain.
  • Paredes R; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Catalonia, Spain.
  • Mateu L; Barcelona Supercomputing Center, 08034 Barcelona, Catalonia, Spain.
  • Chamorro A; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Catalonia, Spain.
  • Massanella M; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Carrillo J; IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Catalonia, Spain.
  • Clotet B; Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital, 08916 Badalona, Catalonia, Spain.
  • Blanco J; Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital, 08916 Badalona, Catalonia, Spain.
Med (N Y) ; 2(3): 313-320.e4, 2021 03 12.
Article in English | MEDLINE | ID: covidwho-1135490
ABSTRACT

BACKGROUND:

Understanding mid-term kinetics of immunity to SARS-CoV-2 is the cornerstone for public health control of the pandemic and vaccine development. However, current evidence is rather based on limited measurements, losing sight of the temporal pattern of these changes.

METHODS:

We conducted a longitudinal analysis on a prospective cohort of COVID-19 patients followed up for >6 months. Neutralizing activity was evaluated using HIV reporter pseudoviruses expressing SARS-CoV-2 S protein. IgG antibody titer was evaluated by ELISA against the S2 subunit, the receptor binding domain (RBD), and the nucleoprotein (NP). Statistical analyses were carried out using mixed-effects models.

FINDINGS:

We found that individuals with mild or asymptomatic infection experienced an insignificant decay in neutralizing activity, which persisted 6 months after symptom onset or diagnosis. Hospitalized individuals showed higher neutralizing titers, which decreased following a 2-phase pattern, with an initial rapid decline that significantly slowed after day 80. Despite this initial decay, neutralizing activity at 6 months remained higher among hospitalized individuals compared to mild symptomatic. The slow decline in neutralizing activity at mid-term contrasted with the steep slope of anti-RBD, S2, or NP antibody titers, all of them showing a constant decline over the follow-up period.

CONCLUSIONS:

Our results reinforce the hypothesis that the quality of the neutralizing immune response against SARS-CoV-2 evolves over the post-convalescent stage.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Med (N Y) Year: 2021 Document Type: Article Affiliation country: J.medj.2021.01.005

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Med (N Y) Year: 2021 Document Type: Article Affiliation country: J.medj.2021.01.005