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Plasma IL-6 levels following corticosteroid therapy as an indicator of ICU length of stay in critically ill COVID-19 patients.
Awasthi, Samir; Wagner, Tyler; Venkatakrishnan, A J; Puranik, Arjun; Hurchik, Matthew; Agarwal, Vineet; Conrad, Ian; Kirkup, Christian; Arunachalam, Raman; O'Horo, John; Kremers, Walter; Kashyap, Rahul; Morice, William; Halamka, John; Williams, Amy W; Faubion, William A; Badley, Andrew D; Gores, Gregory J; Soundararajan, Venky.
  • Awasthi S; nference, Cambridge, MA, 02142, USA.
  • Wagner T; nference, Cambridge, MA, 02142, USA.
  • Venkatakrishnan AJ; nference, Cambridge, MA, 02142, USA.
  • Puranik A; nference, Cambridge, MA, 02142, USA.
  • Hurchik M; nference, Cambridge, MA, 02142, USA.
  • Agarwal V; nference, Cambridge, MA, 02142, USA.
  • Conrad I; nference, Cambridge, MA, 02142, USA.
  • Kirkup C; nference, Cambridge, MA, 02142, USA.
  • Arunachalam R; nference Labs, Bangalore, India.
  • O'Horo J; Mayo Clinic, Rochester, MN, 55905, USA.
  • Kremers W; Mayo Clinic, Rochester, MN, 55905, USA.
  • Kashyap R; Mayo Clinic, Rochester, MN, 55905, USA.
  • Morice W; Mayo Clinic, Rochester, MN, 55905, USA.
  • Halamka J; Mayo Clinic Laboratories, Rochester, MN, 55905, USA.
  • Williams AW; Mayo Clinic, Rochester, MN, 55905, USA.
  • Faubion WA; Mayo Clinic Platform, Rochester, MN, 55905, USA.
  • Badley AD; Mayo Clinic, Rochester, MN, 55905, USA.
  • Gores GJ; Mayo Clinic, Rochester, MN, 55905, USA.
  • Soundararajan V; Mayo Clinic, Rochester, MN, 55905, USA.
Cell Death Discov ; 7(1): 55, 2021 Mar 15.
Article in English | MEDLINE | ID: covidwho-1135657
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
Semantic information from SemMedBD (by NLM)
1. Plasma LOCATION_OF interleukin-6
Subject
Plasma
Predicate
LOCATION_OF
Object
interleukin-6
2. Steroid therapy TREATS COVID-19
Subject
Steroid therapy
Predicate
TREATS
Object
COVID-19
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. Steroid therapy TREATS Patients
Subject
Steroid therapy
Predicate
TREATS
Object
Patients
5. Hospital admission TREATS COVID-19
Subject
Hospital admission
Predicate
TREATS
Object
COVID-19
6. Hospital admission TREATS Patients
Subject
Hospital admission
Predicate
TREATS
Object
Patients
7. dexamethasone TREATS COVID-19
Subject
dexamethasone
Predicate
TREATS
Object
COVID-19
8. dexamethasone TREATS Patients
Subject
dexamethasone
Predicate
TREATS
Object
Patients
9. Adrenal Cortex Hormones NEG_ADMINISTERED_TO Patients
Subject
Adrenal Cortex Hormones
Predicate
NEG_ADMINISTERED_TO
Object
Patients
10. Cells LOCATION_OF interleukin-6
Subject
Cells
Predicate
LOCATION_OF
Object
interleukin-6
11. interleukin-6 ASSOCIATED_WITH COVID-19
Subject
interleukin-6
Predicate
ASSOCIATED_WITH
Object
COVID-19
12. Macrophage PRODUCES 2908
Subject
Macrophage
Predicate
PRODUCES
Object
2908
13. Endothelial Cells PRODUCES NR3C1
Subject
Endothelial Cells
Predicate
PRODUCES
Object
NR3C1
14. Endothelial Cells PRODUCES interleukin-6
Subject
Endothelial Cells
Predicate
PRODUCES
Object
interleukin-6
15. Myocyte PRODUCES 2908
Subject
Myocyte
Predicate
PRODUCES
Object
2908
16. Myocyte PRODUCES C0021760
Subject
Myocyte
Predicate
PRODUCES
Object
C0021760
17. Macrophage PRODUCES C0021760
Subject
Macrophage
Predicate
PRODUCES
Object
C0021760
18. Plasma LOCATION_OF interleukin-6
Subject
Plasma
Predicate
LOCATION_OF
Object
interleukin-6
19. Steroid therapy TREATS COVID-19
Subject
Steroid therapy
Predicate
TREATS
Object
COVID-19
20. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
21. Steroid therapy TREATS Patients
Subject
Steroid therapy
Predicate
TREATS
Object
Patients
22. Hospital admission TREATS COVID-19
Subject
Hospital admission
Predicate
TREATS
Object
COVID-19
23. Hospital admission TREATS Patients
Subject
Hospital admission
Predicate
TREATS
Object
Patients
24. dexamethasone TREATS COVID-19
Subject
dexamethasone
Predicate
TREATS
Object
COVID-19
25. dexamethasone TREATS Patients
Subject
dexamethasone
Predicate
TREATS
Object
Patients
26. Adrenal Cortex Hormones NEG_ADMINISTERED_TO Patients
Subject
Adrenal Cortex Hormones
Predicate
NEG_ADMINISTERED_TO
Object
Patients
27. Cells LOCATION_OF interleukin-6
Subject
Cells
Predicate
LOCATION_OF
Object
interleukin-6
28. interleukin-6 ASSOCIATED_WITH COVID-19
Subject
interleukin-6
Predicate
ASSOCIATED_WITH
Object
COVID-19
29. Macrophages, Alveolar PRODUCES NR3C1
Subject
Macrophages, Alveolar
Predicate
PRODUCES
Object
NR3C1
30. Endothelial Cells PRODUCES NR3C1
Subject
Endothelial Cells
Predicate
PRODUCES
Object
NR3C1
31. Endothelial Cells PRODUCES interleukin-6
Subject
Endothelial Cells
Predicate
PRODUCES
Object
interleukin-6
32. Myocytes, Smooth Muscle PRODUCES NR3C1
Subject
Myocytes, Smooth Muscle
Predicate
PRODUCES
Object
NR3C1
33. Myocytes, Smooth Muscle PRODUCES interleukin-6
Subject
Myocytes, Smooth Muscle
Predicate
PRODUCES
Object
interleukin-6
34. Macrophages, Alveolar PRODUCES interleukin-6
Subject
Macrophages, Alveolar
Predicate
PRODUCES
Object
interleukin-6
ABSTRACT
Intensive care unit (ICU) admissions and mortality in severe COVID-19 patients are driven by "cytokine storms" and acute respiratory distress syndrome (ARDS). Interim clinical trial results suggest that the corticosteroid dexamethasone displays better 28-day survival in severe COVID-19 patients requiring ventilation or oxygen. In this study, 10 out of 16 patients (62.5%) that had an average plasma IL-6 value over 10 pg/mL post administration of corticosteroids also had worse outcomes (i.e., ICU stay >15 days or death), compared to 8 out of 41 patients (19.5%) who did not receive corticosteroids (p-value = 0.0024). Given this potential association between post-corticosteroid IL-6 levels and COVID-19 severity, we hypothesized that the glucocorticoid receptor (GR or NR3C1) may be coupled to IL-6 expression in specific cell types that govern cytokine release syndrome (CRS). Examining single-cell RNA-seq data from BALF of severe COVID-19 patients and nearly 2 million cells from a pan-tissue scan shows that alveolar macrophages, smooth muscle cells, and endothelial cells co-express NR3C1 and IL-6, motivating future studies on the links between the regulation of NR3C1 function and IL-6 levels.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Language: English Journal: Cell Death Discov Year: 2021 Document Type: Article Affiliation country: S41420-021-00429-9

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Language: English Journal: Cell Death Discov Year: 2021 Document Type: Article Affiliation country: S41420-021-00429-9