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COVID-19-associated invasive pulmonary aspergillosis in a tertiary care center in Mexico City.
Vélez Pintado, Mariana; Camiro-Zúñiga, Antonio; Aguilar Soto, Mercedes; Cuenca, Dalia; Mercado, Moisés; Crabtree-Ramirez, Brenda.
  • Vélez Pintado M; Department of Medicine, Centro Médico ABC, Mexico City, Mexico. Sur 136 No. 116, Col. Las Américas, Álvaro Obregón, 01120.
  • Camiro-Zúñiga A; Department of Medicine, Centro Médico ABC, Mexico City, Mexico. Sur 136 No. 116, Col. Las Américas, Álvaro Obregón, 01120.
  • Aguilar Soto M; Department of Medicine, Centro Médico ABC, Mexico City, Mexico. Sur 136 No. 116, Col. Las Américas, Álvaro Obregón, 01120.
  • Cuenca D; Department of Medicine, Centro Médico ABC, Mexico City, Mexico. Sur 136 No. 116, Col. Las Américas, Álvaro Obregón, 01120.
  • Mercado M; Research Unit in Endocrine Diseases, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City. Av. Cuauhtémoc 330, Doctores, Cuauhtémoc, 06720.
  • Crabtree-Ramirez B; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Belisario Domínguez Secc 16, Tlalpan, 14080 Ciudad de México, CDMX.
Med Mycol ; 59(8): 828-833, 2021 Jul 14.
Article in English | MEDLINE | ID: covidwho-1135873
ABSTRACT
Invasive pulmonary aspergillosis (IPA) is a severe infection caused by aspergillus sp. that usually develops in patients with severe immunosuppression. IPA has been recently described in critically ill COVID-19 patients (termed as COVID-associated pulmonary aspergillosis, or CAPA) that are otherwise immunocompetent. In order to describe the characteristics of patients with CAPA, we conducted a retrospective cohort study in a tertiary care center in Mexico City. We included all patients with confirmed COVID-19 admitted to the intensive care unit that had serum or bronchoalveolar lavage galactomannan measurements. We used the criteria proposed by Koehler et al. to establish the diagnosis of CAPA. Main outcomes were the need for invasive mechanical ventilation (IMV) and in-hospital mortality. Out of a total of 83 hospitalized patients with COVID-19 in the ICU, 16 (19.3%) met the criteria for CAPA. All patients diagnosed with CAPA required IMV whereas only 84% of the patients in the non-IPA group needed this intervention (P = 0.09). In the IPA group, 31% (n = 5) of the patients died, compared to 13% (n = 9) in the non-CAPA group (P = 0.08). We conclude that CAPA is a frequent co-infection in critically ill COVID-19 patients and is associated with a high mortality rate. The timely diagnosis and treatment of IPA in these patients is likely to improve their outcome. LAY

SUMMARY:

We studied the characteristics of patients with COVID-19-associated invasive pulmonary aspergillosis (CAPA). Patients with CAPA tended to need invasive mechanical ventilation more frequently and to have a higher mortality rate. Adequate resources for its management can improve their outcome.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Invasive Pulmonary Aspergillosis / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Mexico Language: English Journal: Med Mycol Journal subject: Veterinary Medicine / Microbiology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Invasive Pulmonary Aspergillosis / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Mexico Language: English Journal: Med Mycol Journal subject: Veterinary Medicine / Microbiology Year: 2021 Document Type: Article