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Recombinant SARS-CoV-2 S Protein Binds to Glycans of the Lactosamine Family in vitro.
Ryzhikov, Alexandr B; Onkhonova, Galina S; Imatdinov, Ilnaz R; Gavrilova, Elena V; Maksyutov, Rinat A; Gordeeva, Elena A; Pazynina, Galina V; Ryzhov, Ivan M; Shilova, Nadezhda V; Bovin, Nicolai V.
  • Ryzhikov AB; Vector State Research Center of Virology and Biotechnology, Rospotrebnadzor, Koltsovo, Novosibirsk Region, 630559, Russia.
  • Onkhonova GS; Vector State Research Center of Virology and Biotechnology, Rospotrebnadzor, Koltsovo, Novosibirsk Region, 630559, Russia.
  • Imatdinov IR; Vector State Research Center of Virology and Biotechnology, Rospotrebnadzor, Koltsovo, Novosibirsk Region, 630559, Russia.
  • Gavrilova EV; Vector State Research Center of Virology and Biotechnology, Rospotrebnadzor, Koltsovo, Novosibirsk Region, 630559, Russia.
  • Maksyutov RA; Vector State Research Center of Virology and Biotechnology, Rospotrebnadzor, Koltsovo, Novosibirsk Region, 630559, Russia.
  • Gordeeva EA; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
  • Pazynina GV; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
  • Ryzhov IM; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
  • Shilova NV; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
  • Bovin NV; Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, 117997, Russia.
Biochemistry (Mosc) ; 86(3): 243-247, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-1136063
ABSTRACT
Many viruses, beside binding to their main cell target, interact with other molecules that promote virus adhesion to the cell; often, these additional targets are glycans. The main receptor for SARS-CoV-2 is a peptide motif in the ACE2 protein. We studied interaction of the recombinant SARS-CoV-2 spike (S) protein with an array of glycoconjugates, including various sialylated, sulfated, and other glycans, and found that the S protein binds some (but not all) glycans of the lactosamine family. We suggest that parallel influenza infection will promote SARS-CoV-2 adhesion to the respiratory epithelial cells due to the unmasking of lactosamine chains by the influenza virus neuraminidase.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polysaccharides / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Amino Sugars Limits: Humans Language: English Journal: Biochemistry (Mosc) Year: 2021 Document Type: Article Affiliation country: S0006297921030019

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polysaccharides / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Amino Sugars Limits: Humans Language: English Journal: Biochemistry (Mosc) Year: 2021 Document Type: Article Affiliation country: S0006297921030019