Your browser doesn't support javascript.
Baseline Characteristics and Outcomes of Cancer Patients Infected with SARS-CoV-2 in the Lombardy Region, Italy (AIOM-L CORONA): A Multicenter, Observational, Ambispective, Cohort Study.
Di Cosimo, Serena; Tagliaferri, Barbara; Generali, Daniele; Giudici, Fabiola; Agustoni, Francesco; Bernardo, Antonio; Borgonovo, Karen; Farina, Gabriella; Luchena, Giovanna; Luciani, Andrea; Nolè, Franco; Palmeri, Laura; Pietrantonio, Filippo; Poggi, Guido; Zucali, Paolo Andrea; Balletti, Emanuela; Catania, Giovanna; Bernocchi, Ottavia; D'Antonio, Federica; Giordano, Monica; Grossi, Francesco; Lasagna, Angioletta; La Verde, Nicla; Manzoni, Mariangela; Montagna, Benedetta; Olgiati, Angelo; Raimondi, Alessandra; Rampinelli, Irene; Verri, Elena; Zaniboni, Alberto; Di Maio, Massimo; Beretta, Giordano; Danova, Marco.
  • Di Cosimo S; Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy.
  • Tagliaferri B; Medical Oncology Unit, ICS Maugeri-IRCCS, 27100 Pavia, Italy.
  • Generali D; Department of Medical, Surgery and Health Sciences, University of Trieste, 34123 Trieste, Italy.
  • Giudici F; Breast Cancer Unit, Azienda Socio Sanitaria Territoriale di Cremona, 26100 Cremona, Italy.
  • Agustoni F; Department of Medical, Surgery and Health Sciences, University of Trieste, 34123 Trieste, Italy.
  • Bernardo A; Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35121 Padova, Italy.
  • Borgonovo K; Medical Oncology Department, Fondazione IRCCS Policlinico "San Matteo", 27100 Pavia, Italy.
  • Farina G; Medical Oncology Unit, ICS Maugeri-IRCCS, 27100 Pavia, Italy.
  • Luchena G; Medical Oncology Unit, ASST Bergamo Ovest, 24047 Treviglio, Bergamo, Italy.
  • Luciani A; Medical Oncology Department, ASST Fatebenefratelli-Sacco, 20146 Milano, Italy.
  • Nolè F; Medical Oncology Unit, ASST-Lariana, 22100 Como, Italy.
  • Palmeri L; Medical Oncology Unit, ASST Bergamo Ovest, 24047 Treviglio, Bergamo, Italy.
  • Pietrantonio F; Division of Urogenital and Head & Neck Tumors, European Institute of Oncology (IEO) IRCCS, 20122 Milano, Italy.
  • Poggi G; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, 20121 Milano, Italy.
  • Zucali PA; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy.
  • Balletti E; Medical Oncology Unit, Institute of Care Città di Pavia, 27100 Pavia, Italy.
  • Catania G; Department of Medical Oncology and Hematology, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy.
  • Bernocchi O; Medical Oncology Unit, ICS Maugeri-IRCCS, 27100 Pavia, Italy.
  • D'Antonio F; Medical Oncology Unit, Azienda Ospedaliera Carlo Poma, 46100 Mantova, Italy.
  • Giordano M; Department of Medical, Surgery and Health Sciences, University of Trieste, 34123 Trieste, Italy.
  • Grossi F; Department of Medical Oncology and Hematology, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy.
  • Lasagna A; Medical Oncology Unit, ASST-Lariana, 22100 Como, Italy.
  • La Verde N; Department of Medical Oncology, Fondazione IRCCS Ca'Grande Ospedale Maggiore Policlinico, 20162 Milano, Italy.
  • Manzoni M; Medical Oncology Department, Fondazione IRCCS Policlinico "San Matteo", 27100 Pavia, Italy.
  • Montagna B; Department of Oncology, Luigi Sacco Hospital-ASST Fatebenefratelli Sacco, Via G.B. Grassi 74, 20157 Milan, Italy.
  • Olgiati A; Department of Medical Oncology, Azienda Ospedaliera "Ospedale Maggiore", 26013 Crema, Italy.
  • Raimondi A; Medical Oncology Unit, Institute of Care Città di Pavia, 27100 Pavia, Italy.
  • Rampinelli I; Department of Internal Medicine and Oncology, ASST di Pavia, 27100 Pavia, Italy.
  • Verri E; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy.
  • Zaniboni A; Medical Oncology Unit, Multimedica Castellanza, 21010 Varese, Italy.
  • Di Maio M; Division of Urogenital and Head & Neck Tumors, European Institute of Oncology (IEO) IRCCS, 20122 Milano, Italy.
  • Beretta G; Medical Oncology Unit, Fondazione Poliambulanza, 25124 Brescia, Italy.
  • Danova M; Medical Oncology Unit, Ordine Mauriziano Hospital, 10128 Torino, Italy.
Cancers (Basel) ; 13(6)2021 Mar 16.
Article in English | MEDLINE | ID: covidwho-1136460
ABSTRACT
Cancer patients may be at high risk of infection and poor outcomes related to SARS-CoV-2. Analyzing their prognosis, examining the effects of baseline characteristics and systemic anti-cancer active therapy (SACT) are critical to their management through the evolving COVID-19 pandemic. The AIOM-L CORONA was a multicenter, observational, ambispective, cohort study, with the intended participation of 26 centers in the Lombardy region (Italy). A total of 231 cases were included between March and September 2020. The median age was 68 years; 151 patients (62.2%) were receiving SACT, mostly chemotherapy. During a median follow-up of 138 days (range 12-218), 93 events occurred. Age ≥60 years, metastatic dissemination, dyspnea, desaturation, and interstitial pneumonia were all independent mortality predictors. Overall SACT had a neutral effect (Odds Ratio [OR] 0.83, 95%Confidence Interval [95%CI] 0.32-2.15); however, metastatic patients receiving SACT were less likely to die as compared to untreated counterparts, after adjusting for other confounding variables (OR 0.23, 95%CI 0.11-0.51, p < 0.001). Among cancer patients infected by SARS-CoV-2, those with metastases were most at risk of death, especially in the absence of SACT. During the ongoing pandemic, these vulnerable patients should avoid exposure to SARS-CoV-2, while treatment adjustments and prioritizing vaccination are being considered according to international recommendations.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Cancers13061324

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Cancers13061324