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The Tissue Renin-Angiotensin System and Its Role in the Pathogenesis of Major Human Diseases: Quo Vadis?
Saravi, Babak; Li, Zhen; Lang, Corinna N; Schmid, Bonaventura; Lang, Frauke K; Grad, Sibylle; Alini, Mauro; Richards, Robert Geoffrey; Schmal, Hagen; Südkamp, Norbert; Lang, Gernot M.
  • Saravi B; AO Research Institute Davos, 7270 Davos, Switzerland.
  • Li Z; Department of Orthopedics and Trauma Surgery, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Lang CN; AO Research Institute Davos, 7270 Davos, Switzerland.
  • Schmid B; Department of Cardiology and Angiology I, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Lang FK; Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Grad S; Department of Emergency Medicine, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Alini M; Department of Obstetrics and Gynecology, Medical Center, Faculty of Medicine, University of Freiburg, 79106, Freiburg, Germany.
  • Richards RG; AO Research Institute Davos, 7270 Davos, Switzerland.
  • Schmal H; AO Research Institute Davos, 7270 Davos, Switzerland.
  • Südkamp N; AO Research Institute Davos, 7270 Davos, Switzerland.
  • Lang GM; Department of Orthopedics and Trauma Surgery, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Cells ; 10(3)2021 03 15.
Article in English | MEDLINE | ID: covidwho-1136461
ABSTRACT
Evidence has arisen in recent years suggesting that a tissue renin-angiotensin system (tRAS) is involved in the progression of various human diseases. This system contains two regulatory pathways a pathological pro-inflammatory pathway containing the Angiotensin Converting Enzyme (ACE)/Angiotensin II (AngII)/Angiotensin II receptor type 1 (AGTR1) axis and a protective anti-inflammatory pathway involving the Angiotensin II receptor type 2 (AGTR2)/ACE2/Ang1-7/MasReceptor axis. Numerous studies reported the positive effects of pathologic tRAS pathway inhibition and protective tRAS pathway stimulation on the treatment of cardiovascular, inflammatory, and autoimmune disease and the progression of neuropathic pain. Cell senescence and aging are known to be related to RAS pathways. Further, this system directly interacts with SARS-CoV 2 and seems to be an important target of interest in the COVID-19 pandemic. This review focuses on the involvement of tRAS in the progression of the mentioned diseases from an interdisciplinary clinical perspective and highlights therapeutic strategies that might be of major clinical importance in the future.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renin-Angiotensin System / Receptors, Angiotensin / Angiotensin-Converting Enzyme Inhibitors / Peptidyl-Dipeptidase A / Angiotensin Receptor Antagonists / COVID-19 Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10030650

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renin-Angiotensin System / Receptors, Angiotensin / Angiotensin-Converting Enzyme Inhibitors / Peptidyl-Dipeptidase A / Angiotensin Receptor Antagonists / COVID-19 Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10030650