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Physical Exercise Moderates the Effects of Disability on Depression in People with Multiple Sclerosis during the COVID-19 Outbreak.
Carotenuto, Antonio; Scandurra, Cristiano; Costabile, Teresa; Lavorgna, Luigi; Borriello, Giovanna; Moiola, Lucia; Inglese, Matilde; Trojsi, Francesca; Petruzzo, Martina; Ianniello, Antonio; Nozzolillo, Agostino; Cellerino, Maria; Boffa, Giacomo; Rosa, Laura; Chiodi, Alessandro; Servillo, Giuseppe; Moccia, Marcello; Bonavita, Simona; Filippi, Massimo; Petracca, Maria; Brescia Morra, Vincenzo; Lanzillo, Roberta.
  • Carotenuto A; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, Italy.
  • Scandurra C; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, Italy.
  • Costabile T; Multiple Sclerosis Centre, II Division of Neurology, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  • Lavorgna L; Department of Advanced Medical and Surgical Sciences, II Clinic of Neurology, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  • Borriello G; MS Center, S. Andrea Hospital, Sapienza University, 00189 Rome, Italy.
  • Moiola L; Neurology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Inglese M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DNOGMI), University of Genoa, 16132 Genoa, Italy.
  • Trojsi F; Department of Neurology, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, Italy.
  • Petruzzo M; Department of Advanced Medical and Surgical Sciences, II Clinic of Neurology, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  • Ianniello A; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, Italy.
  • Nozzolillo A; MS Center, S. Andrea Hospital, Sapienza University, 00189 Rome, Italy.
  • Cellerino M; Neurology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Boffa G; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DNOGMI), University of Genoa, 16132 Genoa, Italy.
  • Rosa L; Department of Neurology, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, Italy.
  • Chiodi A; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DNOGMI), University of Genoa, 16132 Genoa, Italy.
  • Servillo G; Department of Neurology, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, Italy.
  • Moccia M; InterUniversity Center for Research in Neurosciences (CIRN), University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  • Bonavita S; Intradepartmental Program of Clinical Psychology, Federico II University Hospital, 80131 Naples, Italy.
  • Filippi M; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, Italy.
  • Petracca M; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, Italy.
  • Brescia Morra V; Department of Advanced Medical and Surgical Sciences, II Clinic of Neurology, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
  • Lanzillo R; Neurology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
J Clin Med ; 10(6)2021 Mar 16.
Article in English | MEDLINE | ID: covidwho-1136516
Semantic information from SemMedBD (by NLM)
1. Depressive disorder PROCESS_OF Persons
Subject
Depressive disorder
Predicate
PROCESS_OF
Object
Persons
2. Multiple Sclerosis AFFECTS Depressive disorder
Subject
Multiple Sclerosis
Predicate
AFFECTS
Object
Depressive disorder
3. Multiple Sclerosis PROCESS_OF Persons
Subject
Multiple Sclerosis
Predicate
PROCESS_OF
Object
Persons
4. Physical disability PROCESS_OF Persons
Subject
Physical disability
Predicate
PROCESS_OF
Object
Persons
5. CD69 protei ASSOCIATED_WITH C0026769
Subject
CD69 protei
Predicate
ASSOCIATED_WITH
Object
C0026769
6. Depressive disorder COEXISTS_WITH COVID-19
Subject
Depressive disorder
Predicate
COEXISTS_WITH
Object
COVID-19
7. Exercise TREATS Multiple Sclerosis
Subject
Exercise
Predicate
TREATS
Object
Multiple Sclerosis
8. Depressive disorder PROCESS_OF Persons
Subject
Depressive disorder
Predicate
PROCESS_OF
Object
Persons
9. Multiple Sclerosis AFFECTS Depressive disorder
Subject
Multiple Sclerosis
Predicate
AFFECTS
Object
Depressive disorder
10. Multiple Sclerosis PROCESS_OF Persons
Subject
Multiple Sclerosis
Predicate
PROCESS_OF
Object
Persons
11. Physical disability PROCESS_OF Persons
Subject
Physical disability
Predicate
PROCESS_OF
Object
Persons
12. CD69 protein, human|CD69 ASSOCIATED_WITH Multiple Sclerosis
Subject
CD69 protein, human|CD69
Predicate
ASSOCIATED_WITH
Object
Multiple Sclerosis
13. Depressive disorder COEXISTS_WITH COVID-19
Subject
Depressive disorder
Predicate
COEXISTS_WITH
Object
COVID-19
14. Exercise TREATS Multiple Sclerosis
Subject
Exercise
Predicate
TREATS
Object
Multiple Sclerosis
ABSTRACT
Physical disability impacts psychosocial wellbeing in people with multiple sclerosis. However, the role of physical activity in this context is still debated. By taking advantage of a previous survey, conducted online from 22 April to 7 May 2020, we performed a post-hoc analysis with the aim to assess the associations between disability, physical exercise, and mental health in multiple sclerosis. We retrieved the following data (i) sociodemographic information, (ii) changes in lifestyle (including exercise), (iii) physical disability, as measured with the Patient-Determined Disease Steps scale, and (iv) anxiety feelings and depressive symptoms assessed via the items included in the Quality of Life in Neurological Disorders measurement system. Examination of the interaction plot showed that the effect of disability on depression, but not on anxious symptoms, was significant for all levels of physical exercise (low b = 1.22, 95% C.I. 0.85, 1.58, p < 0.001; moderate b = 0.95, 95% C.I. 0.66, 1.24, p < 0.001; and high b = 0.68, 95% C.I. 0.24, 1.13, p = 0.003). Based on these data, we can conclude that disability significantly impacted depression during the COVID-19 pandemic, with physical activity playing a moderating role. Our results suggest that favoring exercise in multiple sclerosis (MS) would ameliorate psychological wellbeing regardless of the level of physical disability.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10061234

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10061234