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CHA2DS2-VASc score and modified CHA2DS2-VASc score can predict mortality and intensive care unit hospitalization in COVID-19 patients.
Gunduz, Ramazan; Yildiz, Bekir Serhat; Ozdemir, Ibrahim Halil; Cetin, Nurullah; Ozen, Mehmet Burak; Bakir, Eren Ozan; Ozgur, Su; Bayturan, Ozgur.
  • Gunduz R; Department of Cardiology, Manisa City Hospital, Manisa, Turkey. ramazankard@yahoo.com.
  • Yildiz BS; Facultyof Medicine, Department of Cardiology, Manisa Celal Bayar University Manisa, Manisa, Turkey.
  • Ozdemir IH; Department of Cardiology, Manisa City Hospital, Manisa, Turkey.
  • Cetin N; Facultyof Medicine, Department of Cardiology, Manisa Celal Bayar University Manisa, Manisa, Turkey.
  • Ozen MB; Department of Cardiology, Manisa City Hospital, Manisa, Turkey.
  • Bakir EO; Facultyof Medicine, Department of Cardiology, Manisa Celal Bayar University Manisa, Manisa, Turkey.
  • Ozgur S; Faculty of Medicine, Department of Biostatistics and Medical Informatics, Ege University, Izmir, Turkey.
  • Bayturan O; Facultyof Medicine, Department of Cardiology, Manisa Celal Bayar University Manisa, Manisa, Turkey.
J Thromb Thrombolysis ; 52(3): 914-924, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1137164
ABSTRACT
In this study, we investigated whether the CHA2DS2-VASc score could be used to estimate the need for hospitalization in the intensive care unit (ICU), the length of stay in the ICU, and mortality in patients with COVID-19. Patients admitted to Merkezefendi State Hospital because of COVID-19 diagnosis confirmed by RNA detection of virus by using polymerase chain reaction between March 24, 2020 and July 6, 2020, were screened retrospectively. The CHA2DS2-VASc and modified CHA2DS2-VASc score of all patients was calculated. Also, we received all patients' complete biochemical markers including D-dimer, Troponin I, and c-reactive protein on admission. We enrolled 1000 patients; 791 were admitted to the general medical service and 209 to the ICU; 82 of these 209 patients died. The ROC curves of the CHA2DS2-VASc and M-CHA2DS2-VASc scores were analyzed. The cut-off values of these scores for predicting mortality were ≥ 3 (2 or under and 3). The CHA2DS2-VASc and M-CHA2DS2-VASc scores had an area under the curve value of 0.89 on the ROC. The sensitivity and specificity of the CHA2DS2-VASc scores were 81.7% and 83.8%, respectively; the sensitivity and specificity of the M-CHA2DS2-VASc scores were 85.3% and 84.1%, respectively. Multivariate logistic regression analysis showed that CHA2DS2-VASc, Troponin I, D-Dimer, and CRP were independent predictors of mortality in COVID-19 patients. Using a simple and easily available scoring system, CHA2DS2-VASc and M-CHA2DS2-VASc scores can be assessed in patients diagnosed with COVID-19. These scores can predict mortality and the need for ICU hospitalization in these patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thromboembolism / Decision Support Techniques / Hospital Mortality / COVID-19 / Hospitalization / Intensive Care Units Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: J Thromb Thrombolysis Journal subject: Vascular Diseases Year: 2021 Document Type: Article Affiliation country: S11239-021-02427-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thromboembolism / Decision Support Techniques / Hospital Mortality / COVID-19 / Hospitalization / Intensive Care Units Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: J Thromb Thrombolysis Journal subject: Vascular Diseases Year: 2021 Document Type: Article Affiliation country: S11239-021-02427-1