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Combination of Hydroxychloroquine Plus Azithromycin As Potential Treatment for COVID-19 Patients: Safety Profile, Drug Interactions, and Management of Toxicity.
Hache, Guillaume; Rolain, Jean Marc; Gautret, Philippe; Deharo, Jean-Claude; Brouqui, Philippe; Raoult, Didier; Honoré, Stéphane.
  • Hache G; Service de Pharmacie, Hôpital de la Timone, APHM, Marseille, France.
  • Rolain JM; Aix Marseille Univ, INSERM, INRAE, C2VN, Marseille, France.
  • Gautret P; IHU-Méditerranée Infection, Marseille, France.
  • Deharo JC; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.
  • Brouqui P; IHU-Méditerranée Infection, Marseille, France.
  • Raoult D; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.
  • Honoré S; Aix Marseille Univ, INSERM, INRAE, C2VN, Marseille, France.
Microb Drug Resist ; 27(3): 281-290, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-1137930
ABSTRACT
The coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2, has recently emerged worldwide. In this context, there is an urgent need to identify safe and effective therapeutic strategies for treatment of such highly contagious disease. We recently reported promising results of combining hydroxychloroquine and azithromycin as an early treatment option. Although ongoing clinical trials are challenging the efficacy of this combination, many clinicians claim the authorization to or have already begun to use it to treat COVID-19 patients worldwide. The aim of this article is to share pharmacology considerations contributing to the rationale of this combination, and to provide safety information to prevent toxicity and drug-drug interactions, based on available evidence.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Azithromycin / COVID-19 Drug Treatment / Hydroxychloroquine / Anti-Bacterial Agents Type of study: Prognostic study Limits: Humans Language: English Journal: Microb Drug Resist Journal subject: Microbiology / Drug Therapy Year: 2021 Document Type: Article Affiliation country: Mdr.2020.0232

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Azithromycin / COVID-19 Drug Treatment / Hydroxychloroquine / Anti-Bacterial Agents Type of study: Prognostic study Limits: Humans Language: English Journal: Microb Drug Resist Journal subject: Microbiology / Drug Therapy Year: 2021 Document Type: Article Affiliation country: Mdr.2020.0232