The prognostic value of IL-8 for the death of severe or critical patients with COVID-19.
Medicine (Baltimore)
; 100(11): e23656, 2021 Mar 19.
Article
in English
| MEDLINE | ID: covidwho-1138003
ABSTRACT
ABSTRACT Inflammation has been believed to contribute to coronavirus disease 2019 (COVID-19). Risk factors for death of COVID-19 pneumonia have not yet been well established.In this retrospective cohort study, we included the deceased patients in COVID-19 specialized ICU with laboratory-confirmed COVID-19 from Guanggu hospital area of Tongji Hospital from February 8th to March 30th. Demographic, clinical, laboratory, and outcome data were extracted from electronic medical records using a standard data collection form. We used Spearman rank correlation and Cox regression analysis to explore the risk factors associated with in-hospital death, especially the association between inflammatory cytokines and death.A total of 205âsevere/critical COVID-19 pneumonia patients were admitted in the COVID-19 specialized ICU and 75 deceased patients were included in the final analysis. The median age of the deceasing patients was 70 years (IQR 65-79). The common symptoms were fever (78.9%), cough (70.4%), and expectoration (39.4%). The BNP and CRP levels were far beyond the normal reference range. In the Spearman rank correlation analysis, IL-8 was found to be significantly associated with the time from onset to death (rs=â-0.30, Pâ=â.034) and that from admission to death (rs=â-0.32, Pâ=â.019). Cox regression showed after adjusting age and sex, IL-8 levels were still significantly associated with the time from onset to death (Pâ=â.003) and that from admission to death (Pâ =â.01).IL-8 levels were associated with in-hospital death in severe/critical COVID-19 patients, which could help clinicians to identify patients with high risk of death at an early stage.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Interleukin-8
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
English
Journal:
Medicine (Baltimore)
Year:
2021
Document Type:
Article
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