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Clinical features and viral RNA shedding of imported and local cases with COVID-19 in Wenzhou, China.
He, Guiqing; Wu, Jing; Huang, Jianping; Schieffelin, John S; Dai, Jianyi; Gamber, Michelle; Hu, Xingzhong; Chen, Quelu; Si, Yang; Sun, Wenjie; Cai, Jing.
  • He G; Department of Infectious Diseases.
  • Wu J; Infectious Diseases Laboratory, Wenzhou Sixth People's Hospital, Wenzhou Central Hospital Medical Group, Affiliated Dingli Clinical Institute of Wenzhou Medical University, Wenzhou.
  • Huang J; Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai.
  • Schieffelin JS; Department of Neurology, Wenzhou Central Hospital, Affiliated Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, China.
  • Dai J; Sections of Infectious Disease, Tulane University School of Medicine, New Orleans, LA.
  • Gamber M; Department of Infectious Diseases.
  • Hu X; School of Health Professions, Division of Public Health, Shenandoah University, Winchester, VA, USA.
  • Chen Q; Department of Clinical Laboratory.
  • Si Y; Department of Radiology, Wenzhou Central Hospital, Affiliated Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, China.
  • Sun W; Department of Radiology, Wenzhou Central Hospital, Affiliated Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, China.
  • Cai J; Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA.
Medicine (Baltimore) ; 100(11): e24826, 2021 Mar 19.
Article in English | MEDLINE | ID: covidwho-1138014
ABSTRACT
ABSTRACT Wenzhou had the highest number of confirmed novel coronavirus 2019 (COVID-19) cases outside the Hubei province. The aim of this study was to identify the difference in clinical features and viral RNA shedding between the imported and local COVID-19 cases in Wenzhou.All patients with confirmed COVID-19 admitted to Wenzhou Sixth People's Hospital, Wenzhou Central Hospital Medical Group, from January 17 to February 11, 2020, were enrolled in this study. Data was analyzed and compared for the imported and local cases with regard to epidemiological, demographic, clinical, radiological features, and laboratory findings. Outcomes for the enrolled participants were followed up until May 7, 2020.Of the 136 cases, 50 were imported from Wuhan. The median age was 45 years and 73 (53.7%) were men. The most common symptoms at onset were fever (104 [76.5%]) and cough (85[62.5%]). Pleural effusion was more common among imported cases compared to local cases. The white blood cell count, neutrophil count, lymphocyte count and platelet count of the imported cases were significantly lower than those of the local cases, while the prothrombin time was significantly longer than that of the local cases. Severe and critically ill patients accounted for 15.4% and 2.9%, respectively. The median duration of SARS-CoV-2 RNA shedding from symptom onset was 26 days (IQR 17-32.3 days) and there were no significant differences in duration of viral RNA shedding between the two groups.The study findings suggest that imported cases from Wuhan were more likely to be severe compared to the local cases in Wenzhou. However, there was no difference between imported and local cases on the viral shedding among the COVID patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Virus Shedding / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Virus Shedding / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article