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A randomized trial in the investigation of anxiety and depression in patients with coronavirus disease 2019 (COVID-19).
Zhou, Feng; Wang, Rong-Rong; Huang, Han-Ping; Du, Chun-Ling; Wu, Chao-Min; Qian, Xue-Mei; Li, Wei-Li; Wang, Ju-Li; Jiang, Lv-Yan; Jiang, Hui-Jia; Yu, Wen-Jie; Cheng, Ke-Bin.
  • Zhou F; Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China; Department of Respiratory Disease, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China; Department of Infectious Disease, Jinyintan Hospital of Wuhan, Wuhan, China.
  • Wang RR; Department of Infectious Disease, Jinyintan Hospital of Wuhan, Wuhan, China; Department of Surgical Intensive Care Unit, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
  • Huang HP; Department of Infectious Disease, Jinyintan Hospital of Wuhan, Wuhan, China.
  • Du CL; Department of Respiratory Disease, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
  • Wu CM; Department of Respiratory Disease, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China; Department of Infectious Disease, Jinyintan Hospital of Wuhan, Wuhan, China.
  • Qian XM; Department of Infectious Disease, Jinyintan Hospital of Wuhan, Wuhan, China; Department of Infectious Disease, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
  • Li WL; Department of Infectious Disease, Jinyintan Hospital of Wuhan, Wuhan, China; Department of Internal Medicine, People's Hospital of Zhujiajiao, Shanghai, China.
  • Wang JL; Department of Respiratory Disease, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China; Department of Infectious Disease, Jinyintan Hospital of Wuhan, Wuhan, China.
  • Jiang LY; Department of Infectious Disease, Jinyintan Hospital of Wuhan, Wuhan, China; Department of Pediatrics, Fengxian Central Hospital, Shanghai, China.
  • Jiang HJ; Department of Infectious Disease, Jinyintan Hospital of Wuhan, Wuhan, China; Department of Orthopedics, Fengxian Central Hospital, Shanghai, China.
  • Yu WJ; Department of Infectious Disease, Jinyintan Hospital of Wuhan, Wuhan, China; Department of Orthopedics, Sijing Hospital of Songjiang, Shanghai, China.
  • Cheng KB; Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. chengkebin2017@163.com.
Ann Palliat Med ; 10(2): 2167-2174, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1138982
ABSTRACT

BACKGROUND:

In March 2020, the World Health Organization (WHO) declared COVID-19 a public health emergency of international concern. A small proportion of patients infected with COVID-19 go on to develop pneumonia. We speculated that COVID-19 may be likely to result in psychological disorders such as anxiety and depression. In this study, we conducted an investigation of anxiety and depression in patients with COVID-19.

METHODS:

Sixty-five COVID-19 patients were randomly enrolled into this study. Anxiety and depression among participants were measured through the completion of anonymous Chinese-language Zung self-rating anxiety scale and self-rating depression scale questionnaires. Data were analyzed using independent samples t-tests, Mann-Whitney U-tests, and χ2 tests.

RESULTS:

The questionnaire results showed that 26.15% and 41.54% of participants suffered from anxiety and depression, respectively, although there was no significantly statistical difference between the proportions of COVID-19 patients with anxiety and depression. Statistically significant differences in employment status, partial pressure of oxygen, and corticosteroid application existed between moderate- and severe COVID-19 patients (P<0.05). In particular, the partial pressure of oxygen was significantly lower in severe COVID-19 patients than in their moderate counter parts (71.31±23.54 vs. 101.06±34.43, U=156, P=0.006). Total lymphocytes was lower in severe group than in moderate group [1.659±0.643 vs. 0.745 (0.645, 0.928), U=109, P=0.000]. Also, a higher proportion of female than male patients had anxiety (χ2=5.388, P=0.02). COVID-19 patients who received antiviral medications also displayed a higher rate of anxiety (χ2=4.481, P=0.034). Total lymphocytes between the non-anxiety and anxiety had statistical difference (U=321, P=0.019). Meanwhile, total lymphocytes between the non-depression and depression also had statistical difference (U=389.5, P=0.01).

CONCLUSIONS:

Among patients with COVID-19, females and those treated with antiviral medications were more likely to experience anxiety. In addition, our findings reflected the effect of anxiety and depression on immune system.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Anxiety / Depression / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Ann Palliat Med Year: 2021 Document Type: Article Affiliation country: Apm-21-212

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Anxiety / Depression / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Ann Palliat Med Year: 2021 Document Type: Article Affiliation country: Apm-21-212