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The Role of Bcl-xL Protein in Viral Infections.
Wyzewski, Zbigniew; Switlik, Weronika; Mielcarska, Matylda Barbara; Gregorczyk-Zboroch, Karolina Paulina.
  • Wyzewski Z; Institute of Biological Sciences, Cardinal Stefan Wyszynski University in Warsaw, 01-815 Warsaw, Poland.
  • Switlik W; Department of Biochemistry and Microbiology, Institute of Biology, Warsaw University of Life Sciences-SGGW, 02-787 Warsaw, Poland.
  • Mielcarska MB; Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.
  • Gregorczyk-Zboroch KP; Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.
Int J Mol Sci ; 22(4)2021 Feb 16.
Article in English | MEDLINE | ID: covidwho-1139186
ABSTRACT
Bcl-xL represents a family of proteins responsible for the regulation of the intrinsic apoptosis pathway. Due to its anti-apoptotic activity, Bcl-xL co-determines the viability of various virally infected cells. Their survival may determine the effectiveness of viral replication and spread, dynamics of systemic infection, and viral pathogenesis. In this paper, we have reviewed the role of Bcl-xL in the context of host infection by eight different RNA and DNA viruses hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), influenza A virus (IAV), Epstein-Barr virus (EBV), human T-lymphotropic virus type-1 (HTLV-1), Maraba virus (MRBV), Schmallenberg virus (SBV) and coronavirus (CoV). We have described an influence of viral infection on the intracellular level of Bcl-xL and discussed the impact of Bcl-xL-dependent cell survival control on infection-accompanying pathogenic events such as tissue damage or oncogenesis. We have also presented anti-viral treatment strategies based on the pharmacological regulation of Bcl-xL expression or activity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Apoptosis / Bcl-X Protein Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22041956

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Apoptosis / Bcl-X Protein Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22041956