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BMI and Outcomes of SARS-CoV-2 Among US Veterans.
Eastment, McKenna C; Berry, Kristin; Locke, Emily; Green, Pamela; O'Hare, Ann; Crothers, Kristina; Dominitz, Jason A; Fan, Vincent S; Shah, Javeed A; Ioannou, George N.
  • Eastment MC; Division of Allergy and Infectious Disease, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington, USA.
  • Berry K; VA Office of Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
  • Locke E; VA Office of Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
  • Green P; VA Office of Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
  • O'Hare A; Division of Nephrology, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington, USA.
  • Crothers K; Division of Pulmonary and Critical Care, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington, USA.
  • Dominitz JA; Division of Gastroenterology, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington, USA.
  • Fan VS; Division of Pulmonary and Critical Care, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington, USA.
  • Shah JA; Division of Allergy and Infectious Disease, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington, USA.
  • Ioannou GN; Division of Gastroenterology, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington, USA.
Obesity (Silver Spring) ; 29(5): 900-908, 2021 05.
Article in English | MEDLINE | ID: covidwho-1139280
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus PROCESS_OF Veterans
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Veterans
2. 2019 novel coronavirus PROCESS_OF Cohort
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Cohort
3. Normal weight PROCESS_OF Persons
Subject
Normal weight
Predicate
PROCESS_OF
Object
Persons
4. American College of Cardiology/American Heart Association Lesion Complexity Score C COEXISTS_WITH Obesity
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
COEXISTS_WITH
Object
Obesity
5. 2019 novel coronavirus PROCESS_OF Veterans
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Veterans
6. 2019 novel coronavirus PROCESS_OF Cohort
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Cohort
7. Normal weight PROCESS_OF Persons
Subject
Normal weight
Predicate
PROCESS_OF
Object
Persons
8. American College of Cardiology/American Heart Association Lesion Complexity Score C COEXISTS_WITH Obesity
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
COEXISTS_WITH
Object
Obesity
ABSTRACT

OBJECTIVE:

The purpose of this study is to examine the associations of BMI with testing positive for severe acute respiratory coronavirus 2 (SARS-CoV-2) and risk of adverse outcomes in a cohort of Veterans Affairs enrollees.

METHOD:

Adjusted relative risks/hazard ratios (HRs) were calculated for the associations between BMI category (underweight, normal weight, overweight, class 1 obesity, class 2 obesity, and class 3 obesity) and testing positive for SARS-CoV-2 or experiencing hospitalization, intensive care unit admission, mechanical ventilation, and death among those testing positive.

RESULTS:

Higher BMI categories were associated with higher risk of a positive SARS-CoV-2 test compared with the normal weight category (class 3 obesity adjusted relative risk 1.34, 95% CI 1.28-1.42). Among 25,952 patients who tested positive for SARS-CoV-2, class 3 obesity was associated with higher risk of mechanical ventilation (adjusted HR [aHR] 1.77, 95% CI 1.35-2.32) and mortality (aHR 1.42, 95% CI 1.12-1.78) compared with normal weight individuals. These associations were present primarily in patients younger than 65 and were attenuated or absent in older age groups (interaction P < 0.05).

CONCLUSION:

Veterans Affairs enrollees with higher BMI were more likely to test positive for SARS-CoV-2 and were more likely to be mechanically ventilated or die if infected with SARS-CoV-2. Higher BMI contributed relatively more to the risk of death in those younger than 65 years of age as compared with other age categories.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Veterans / Body Mass Index / COVID-19 / Obesity Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Obesity (Silver Spring) Journal subject: Nutritional Sciences / Physiology / Metabolism Year: 2021 Document Type: Article Affiliation country: Oby.23111

Full text: Available Collection: International databases Database: MEDLINE Main subject: Veterans / Body Mass Index / COVID-19 / Obesity Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Obesity (Silver Spring) Journal subject: Nutritional Sciences / Physiology / Metabolism Year: 2021 Document Type: Article Affiliation country: Oby.23111