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Host-directed editing of the SARS-CoV-2 genome.
Mourier, Tobias; Sadykov, Mukhtar; Carr, Michael J; Gonzalez, Gabriel; Hall, William W; Pain, Arnab.
  • Mourier T; King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE), Thuwal-Jeddah, 23955-6900, Saudi Arabia. Electronic address: tobias.mourier@kaust.edu.sa.
  • Sadykov M; King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE), Thuwal-Jeddah, 23955-6900, Saudi Arabia.
  • Carr MJ; National Virus Reference Laboratory (NVRL), School of Medicine, University College Dublin, Belfield, D04 V1W8, Dublin, Ireland; Research Center for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, N20 W10 Kita-ku, Sapporo, 001-0020, Japan.
  • Gonzalez G; National Virus Reference Laboratory (NVRL), School of Medicine, University College Dublin, Belfield, D04 V1W8, Dublin, Ireland; Research Center for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, N20 W10 Kita-ku, Sapporo, 001-0020, Japan.
  • Hall WW; National Virus Reference Laboratory (NVRL), School of Medicine, University College Dublin, Belfield, D04 V1W8, Dublin, Ireland; Research Center for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, N20 W10 Kita-ku, Sapporo, 001-0020, Japan;
  • Pain A; King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE), Thuwal-Jeddah, 23955-6900, Saudi Arabia; Research Center for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE),
Biochem Biophys Res Commun ; 538: 35-39, 2021 01 29.
Article in English | MEDLINE | ID: covidwho-1139448
ABSTRACT
The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adenosine Deaminase / RNA-Binding Proteins / Genome, Viral / Host-Pathogen Interactions / APOBEC Deaminases / Gene Editing / SARS-CoV-2 / COVID-19 Type of study: Observational study Limits: Humans Language: English Journal: Biochem Biophys Res Commun Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adenosine Deaminase / RNA-Binding Proteins / Genome, Viral / Host-Pathogen Interactions / APOBEC Deaminases / Gene Editing / SARS-CoV-2 / COVID-19 Type of study: Observational study Limits: Humans Language: English Journal: Biochem Biophys Res Commun Year: 2021 Document Type: Article