Immunotoxic role of organophosphates: An unseen risk escalating SARS-CoV-2 pathogenicity.
Food Chem Toxicol
; 149: 112007, 2021 Mar.
Article
in English
| MEDLINE | ID: covidwho-1139498
ABSTRACT
Consistent gathering of immunotoxic substances on earth is a serious global issue affecting people under pathogenic stress. Organophosphates are among such hazardous compounds that are ubiquitous in nature. They fuel oxidative stress to impair antiviral immune response in living entities. Aside, organophosphates promote cytokine burst and pyroptosis in broncho-alveolar chambers leading to severe respiratory ailments. At present, we witness COVID-19 outbreak caused by SARS-CoV-2. Infection triggers cytokine storm coupled with inflammatory manifestations and pulmonary disorders in patients. Since organophosphate-exposure promotes necroinflammation and respiratory troubles hence during current pandemic situation, additional exposure to such chemicals can exacerbate inflammatory outcome and pulmonary maladies in patients, or pre-exposure to organophosphates might turn-out to be a risk factor for compromised immunity. Fortunately, antioxidants alleviate organophosphate-induced immunosuppression and hence under co-exposure circumstances, dietary intake of antioxidants would be beneficial to boost immunity against SARS-CoV-2 infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Organophosphates
/
Oxidative Stress
/
Environmental Exposure
/
SARS-CoV-2
/
COVID-19
/
Immunity
/
Inflammation
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Food Chem Toxicol
Year:
2021
Document Type:
Article
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