Your browser doesn't support javascript.
Incidence, Characteristics and Outcomes of Large Vessel Stroke in COVID-19 Cohort: An International Multicenter Study.
Khandelwal, Priyank; Al-Mufti, Fawaz; Tiwari, Ambooj; Singla, Amit; Dmytriw, Adam A; Piano, Mariangela; Quilici, Luca; Pero, Guglielmo; Renieri, Leonardo; Limbucci, Nicola; Martínez-Galdámez, Mario; Schüller-Arteaga, Miguel; Galván, Jorge; Arenillas-Lara, Juan Francisco; Hashim, Zafar; Nayak, Sanjeev; Desousa, Keith; Sun, Hai; Agarwalla, Pankaj K; Nanda, Anil; Roychowdhury, J Sudipta; Nourollahzadeh, Emad; Prakash, Tannavi; Gandhi, Chirag D; Xavier, Andrew R; Lozano, J Diego; Gupta, Gaurav; Yavagal, Dileep R.
  • Khandelwal P; Department of Neurological Surgery, University Hospital Newark, New Jersey Medical School, Rutgers, New Jersey, USA.
  • Al-Mufti F; Department of Neurology, Radiology, and Neurosurgery, Westchester Medical Center at NY Medical College, Valhalla, New York, USA.
  • Tiwari A; Department of Neurology, Brookdale and Jamaica Hospital Center, NYU School of Medicine, Brooklyn, New York, USA.
  • Singla A; Department of Neurological Surgery, University Hospital Newark, New Jersey Medical School, Rutgers, New Jersey, USA.
  • Dmytriw AA; Neuroradiology and Neurointervention Service, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Piano M; Department of Neuroradiology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Quilici L; Department of Neuroradiology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Pero G; Department of Neuroradiology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Renieri L; Department of Radiology, Neurovascular Unit, Careggi University Hospital, Florence, Italy.
  • Limbucci N; Department of Radiology, Neurovascular Unit, Careggi University Hospital, Florence, Italy.
  • Martínez-Galdámez M; Department of Interventional Neuroradiology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
  • Schüller-Arteaga M; Department of Interventional Neuroradiology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
  • Galván J; Department of Interventional Neuroradiology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
  • Arenillas-Lara JF; Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
  • Hashim Z; Department of Radiology, University Hospital of North Midlands, Stoke-on-Trent, United Kingdom.
  • Nayak S; Department of Radiology, University Hospital of North Midlands, Stoke-on-Trent, United Kingdom.
  • Desousa K; Department of Neurology, Eastern Region, Northwell Health, Long Island, New York, New York, USA.
  • Sun H; Department of Neurological Surgery, Rutgers Robert Wood Johnson Medical School, New Jersey Medical School, New Brunswick, New Jersey, USA.
  • Agarwalla PK; Department of Neurological Surgery, University Hospital Newark, New Jersey Medical School, Rutgers, New Jersey, USA.
  • Nanda A; Department of Neurological Surgery, University Hospital Newark, New Jersey Medical School, Rutgers, New Jersey, USA.
  • Roychowdhury JS; Department of Neurology & Radiology, Robert Wood Johnson University Hospital, Rutgers, New Jersey, USA.
  • Nourollahzadeh E; Department of Neurology & Radiology, Robert Wood Johnson University Hospital, Rutgers, New Jersey, USA.
  • Prakash T; Department of Neurological Surgery, University Hospital Newark, New Jersey Medical School, Rutgers, New Jersey, USA.
  • Gandhi CD; Department of Neurosurgery, Westchester Medical Center at NY Medical College, Valhalla, New York, USA.
  • Xavier AR; Department of Neurology, Saint Joseph Health, Detroit Medical Center, Detroit, Michigan, USA.
  • Lozano JD; Department of Radiology, University of California Riverside, Riverside, California, USA.
  • Gupta G; Department of Neurological Surgery, Rutgers Robert Wood Johnson Medical School, New Jersey Medical School, New Brunswick, New Jersey, USA.
  • Yavagal DR; Department of Neurology, Miller School of Medicine, Miami, Florida, USA.
Neurosurgery ; 89(1): E35-E41, 2021 06 15.
Article in English | MEDLINE | ID: covidwho-1139998
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Cohort
Subject
COVID-19
Predicate
PROCESS_OF
Object
Cohort
2. Cerebrovascular accident OCCURS_IN Cohort
Subject
Cerebrovascular accident
Predicate
OCCURS_IN
Object
Cohort
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. Acute Ischemic Stroke PROCESS_OF Patients
Subject
Acute Ischemic Stroke
Predicate
PROCESS_OF
Object
Patients
5. Acute Ischemic Stroke OCCURS_IN Patients
Subject
Acute Ischemic Stroke
Predicate
OCCURS_IN
Object
Patients
6. Stroke Center LOCATION_OF Multicenter Study
Subject
Stroke Center
Predicate
LOCATION_OF
Object
Multicenter Study
7. Mechanical thrombectomy TREATS hospitalized patients
Subject
Mechanical thrombectomy
Predicate
TREATS
Object
hospitalized patients
8. Vascular occlusion OCCURS_IN Patients
Subject
Vascular occlusion
Predicate
OCCURS_IN
Object
Patients
9. COVID-19 PROCESS_OF Cohort
Subject
COVID-19
Predicate
PROCESS_OF
Object
Cohort
10. Cerebrovascular accident OCCURS_IN Cohort
Subject
Cerebrovascular accident
Predicate
OCCURS_IN
Object
Cohort
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
12. Acute Ischemic Stroke PROCESS_OF Patients
Subject
Acute Ischemic Stroke
Predicate
PROCESS_OF
Object
Patients
13. Acute Ischemic Stroke OCCURS_IN Patients
Subject
Acute Ischemic Stroke
Predicate
OCCURS_IN
Object
Patients
14. Stroke Center LOCATION_OF Multicenter Study
Subject
Stroke Center
Predicate
LOCATION_OF
Object
Multicenter Study
15. Mechanical thrombectomy TREATS hospitalized patients
Subject
Mechanical thrombectomy
Predicate
TREATS
Object
hospitalized patients
16. Vascular occlusion OCCURS_IN Patients
Subject
Vascular occlusion
Predicate
OCCURS_IN
Object
Patients
ABSTRACT

BACKGROUND:

While there are reports of acute ischemic stroke (AIS) in coronavirus disease 2019 (COVID-19) patients, the overall incidence of AIS and clinical characteristics of large vessel occlusion (LVO) remain unclear.

OBJECTIVE:

To attempt to establish incidence of AIS in COVID-19 patients in an international cohort.

METHODS:

A cross-sectional retrospective, multicenter study of consecutive patients admitted with AIS and COVID-19 was undertaken from March 1 to May 1, 2020 at 12 stroke centers from 4 countries. Out of those 12 centers, 9 centers admitted all types of strokes and data from those were used to calculate the incidence rate of AIS. Three centers exclusively transferred LVO stroke (LVOs) patients and were excluded only for the purposes of calculating the incidence of AIS. Detailed data were collected on consecutive LVOs in hospitalized patients who underwent mechanical thrombectomy (MT) across all 12 centers.

RESULTS:

Out of 6698 COVID-19 patients admitted to 9 stroke centers, the incidence of stroke was found to be 1.3% (interquartile range [IQR] 0.75%-1.7%). The median age of LVOs patients was 51 yr (IQR 50-75 yr), and in the US centers, African Americans comprised 28% of patients. Out of 66 LVOs, 10 patients (16%) were less than 50 yr of age. Among the LVOs eligible for MT, the average time from symptom onset to presentation was 558 min (IQR 82-695 min). A total of 21 (50%) patients were either discharged to home or discharged to acute rehabilitation facilities.

CONCLUSION:

LVO was predominant in patients with AIS and COVID-19 across 2 continents, occurring at a significantly younger age and affecting African Americans disproportionately in the USA.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Ischemia / Ischemic Stroke / COVID-19 Type of study: Controlled clinical trial / Etiology study / Incidence study / Observational study / Prevalence study / Prognostic study / Randomized controlled trials / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Neurosurgery Year: 2021 Document Type: Article Affiliation country: Neuros

Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Ischemia / Ischemic Stroke / COVID-19 Type of study: Controlled clinical trial / Etiology study / Incidence study / Observational study / Prevalence study / Prognostic study / Randomized controlled trials / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Neurosurgery Year: 2021 Document Type: Article Affiliation country: Neuros